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Preface
Contributors
Sect. 1 Introduction to Adrenal Gland Involvement in Toxicology 1
1 An overview of adrenal gland involvement in toxicology: from target organ to stress and glucocorticosteroid modulation of toxicity 3
Sect. 2 General Endocrinology, Pharmacology and Pathology of the Adrenal Gland Related to Species, Sex and Age and Glucocorticosteroid Actions 21
2 Adrenal morphology and hormone synthesis and regulation 23
3 Transport, actions and metabolism of adrenal hormones and pathology and pharmacology of the adrenal gland 53
4 Molecular and systems pharmacology of glucocorticosteroids 81
Sect. 3 The Adrenal Gland as a Target Organ 129
5 The adrenal cortex as a toxicological target organ 131
6 The adrenal medulla as a toxicological target organ 165
Sect. 4 Adrenocortical and Glucocorticosteroid Modulation of Toxicity 183
7 Glucocorticosteroid modulation of toxicity 185
8 Glucocorticosteroids: deleterious effects on neurons and potential exacerbation of environmental neurotoxicity 205
9 Glucocorticosteroids, stress and developmental toxicology 223
10 Glucocorticosteroids and immunotoxicity 243
Sect. 5 Clinical Interfaces: Adrenal and Corticosteroid Involvement in Human Toxicology and Extrapolation to Man 259
11 Corticosteroid adverse effects and drug interactions in man 261
12 Adverse drug reactions and the adrenal glands: a pharmacoepidemiological approach 279
13 Experimental adrenal toxicity: significance of findings and relevance to man 301
Index 307