Molecular Oncology of Breast Cancer

Author: Jeffrey S. Ross
Published: November 2004
Publisher: Jones & Bartlett Publishers, Inc.
ISBN: 0763748102
Hardcover Book
Number of Pages: 450

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The first comprehensive reference to focus on the molecular development and treatment of the disease, Molecular Oncology of Breast Cancer provides authoritative information across the spectrum of modern breast cancer research and clinical care. Edited by two world-class experts in cancer pathology, drug development, and patient management, with contributions from over 50 experts, this groundbreaking text describes the genes, proteins, and biologic pathways that are being evaluated today and will be tested in the future to derive the molecular signature of each newly diagnosed breast cancer. For the first time, readers can now obtain, in a single volume, up to date information on how molecular-based tests are being used to identify predisposition, provide earliest detection, decide classification based on genetic fingerprint, and predict therapy-specific outcomes. MOBC includes unique chapters on functional imaging and the impact of targeted therapies on the FDA approval process. This book gives readers vital, up-to-date information on important molecular discoveries that affect the everyday management of the breast cancer patient.

Table of Contents
Foreword
Preface
Ch. 1 Introduction and background 1
Ch. 2 Molecular diagnostic techniques in breast cancer 12
Ch. 3 Clinical and molecular epidemiology of breast cancer 34
Ch. 4 Predisposition for breast cancer 48
Ch. 5 Screening and early detection, serum and nipple aspirates, routine and molecular methods including reverse transcriptase-polymerase chain reaction, and proteomics 60
Ch. 6 Genomic and molecular classification of breast cancer 81
Ch. 7 Cytology : clinical sample procurement and on-slide technologies 96
Ch. 8 Histopathology of breast cancer : correlation with molecular markers 106
Ch. 9 Sentinel lymph node dissection and micrometastasis detection in bone marrow and lymph nodes 117
Ch. 10 Prognostic and predictive factors overview 128
Ch. 11 Breast cancer cytogenetics, chromosomal abnormalities, and comparative genomic hybridization 142
Ch. 12 DNA ploidy and S phase analysis in breast cancer 153
Ch. 13 Cell proliferation markers and cell cycle regulators in breast cancer 169
Ch. 14 Targeted therapy for cancer : integrating diagnostics and therapeutics 192
Ch. 15 Hormone receptors and hormonal-based therapy for breast cancer 207
Ch. 16 HER-2/neu gene and protein in breast cancer 232
Ch. 17 Epidermal growth factor receptor and other growth factors and receptors 256
Ch. 18 Tumor-associated proteolytic factors : markers for tumor invasion and metastasis 276
Ch. 19 Breast cancer and angiogenesis 289
Ch. 20 Cell adhesion markers 313
Ch. 21 Programmed cell death and breast cancer 322
Ch. 22 Oncogenes 348
Ch. 23 P53 and tumor suppressor genes in breast cancer 358
Ch. 24 The ubiquitin-proteasome pathway and breast cancer 373
Ch. 25 DNA repair and the maintenance of genomic stability in breast cancer 394
Ch. 26 Biologic and clinical significance of DNA gene methylation and epigenetic events in breast cancer 411
Ch. 27 DNA methylation in breast cancer as diagnostic markers and targets for cancer therapy 422
Ch. 28 Pharmacogenetics, pharmacogenomics, and predicting response to therapy 439
Ch. 29 Mammography and molecular imaging 457
Ch. 30 Translation of molecular markers to clinical practice 469
Ch. 31 Regulatory aspects and implications of molecular testing in the United States 478

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