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Table of Contents:

Contributors
Preface
TNM Cancer Staging
Acknowledgments
1 The Discipline of Radiation Oncology 1
2 Biologic Basis of Radiation Therapy 96
3 Molecular Cancer and Radiation Biology 137
4 Molecular Pathophysiology of Tumors 163
5 Principles of Radiologic Physics, Dosimetry, and Treatment Planning 180
6 Photon External-Beam Dosimetry and Treatment Planning 219
7 Electron-Beam Therapy: Dosimetry, Planning, and Techniques 252
8 Three-Dimensional Conformal Radiation Therapy: Physics, Treatment Planning, and Clinical Aspects 283
9 Intensity-Modulated Radiation Treatment Planning, Quality Assurance, Delivery, and Clinical Application 314
10 Altered Fractionation Schedules 337
11 Late Effects of Cancer Treatment on Normal Tissues 357
12 Methodology of Clinical Trials 391
13 Magna-Field Irradiation 400
14 Stereotactic Irradiation 410
15 Intraoperative Radiation Therapy 428
16 Particle Beam Radiotherapy: Clinical Perspective 457
17 Physics and Biology of Brachytherapy 472
18 Clinical Applications of Brachytherapy I. LDR and PDR 538
19 Physics and Dosimetry of High-Dose-Rate Brachytherapy 604
20 Clinical Aspects of High-Dose-Rate Brachytherapy 619
21 Nonsealed Radionuclide Therapy 636
22 Radioimmunoglobulins in Cancer Therapy 653
23 Radiation Response Modulation 663
Pt. A Chemical Sensitizers and Protectors
Pt. B Biological Response Modifiers
24 Hyperthermia 699
25 Basic Concepts of Chemotherapy and Irradiation Interaction 736
26 Skin 757
27 Malignant Neoplasms Associated with the Acquired Immunodeficiency Syndrome (AIDS) 776
28 Brian, Brain Stem, and Cerebellum 791
29 Pituitary 839
30 Spinal Canal 860
31 Eye and Orbit 876
32 Ear 897
33 The Role of Combined Radiation Therapy and Chemotherapy in the Management of Locally Advanced Squamous Carcinoma of the Head and Neck 905
34 Nasopharynx 918
35 Nasal Cavity and Paranasal Sinuses 962
36 Salivary Glands 976
37 Oral Cavity 997
38 Oropharynx (Tonsillar Fossa, Faucial Arch, and Base of Tongue) 1022
39 Hypopharynx 1071
40 Larynx 1094
41 Unusual Nonepithelial Tumors of the Head and Neck 1117
42 Head and Neck: Management of the Neck 1158
43 Thyroid 1179
44 Lung 1201
45 Mediastinum and Trachea 1244
46 Esophagus 1282
47 Tumors of the Heart and Great Vessels 1305
48 Breast: Stage Tis 1315
49 Breast: Stage T1 and T2 Tumors 1331
50 Breast: Locally Advanced (T3 and T4) and Recurrent Tumors 1502
51 Stomach 1554
52 Cancer of the Pancreas 1574
53 Liver and Hepatobiliary Tract 1589
54 Colon and Rectum 1607
55 Anal Canal 1630
56 Kidney, Renal Pelvis, and Ureter 1649
57 Bladder 1664
58 Prostate Cancer 1692
59 Testis 1763
60 Penis and Male Urethra 1785
61 Uterine Cervix 1800
62 Endometrium 1916
63 Ovary 1934
64 Fallopian Tube 1958
65 Vagina 1967
66 Female Urethra 1994
67 Carcinoma of the Vulva 2003
68 Retroperitoneum 2023
69 Adrenal Gland 2036
70 Hodgkin's Disease 2043
71 Non-Hodgkin's Lymphoma 2064
72 Cutaneous T-Cell Lymphoma 2112
73 Leukemia 2125
74 Myeloma and Plasmacytomas 2157
75 Bone 2168
76 Soft Tissue Sarcomas (Excluding Retroperitoneum) 2185
77 Central Nervous System Tumors in Children 2206
78 Wilms' Tumor 2238
79 Neuroblastoma 2247
80 Rhabdomyosarcoma 2261
81 Ewing's Sarcoma 2277
82 Lymphomas in Children 2285
83 Unusual Tumors in Childhood 2308
84 Radiation Treatment of Benign Disease 2332
85 Endovascular Brachytherapy 2352
86 Palliation of Brain and Spinal-Cord Metastases 2373
87 Palliation of Bone Metastases 2385
88 Palliation of Visceral Recurrences and Metastases 2405
89 Pain Management 2412
90 Supportive Care and Quality of Life in Radiation Oncology 2426
91 Technology Assessment, Cost Benefit, Outcome Research, and Evidence-Based Medicine 2443
92 Ethics, Professional Values, and Legal Considerations in Radiation Oncology 2461
Index 2471