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• Each section includes a series of "Approach to Patients" chapters focusing on evaluation and work-up.
• Provides complete descriptions of disease-specific entities, with "Indications for Referrals" and "Indications for Hospitalization" highlighted for quick reference.
• A "Rapid Access Guide" at the front of the book summarizes key facts pertaining to the most important disease entities or clinical problems.

• Evidenced based clinical decision aids - approximately 120 algorithms have been added with this edition. Each algorithm provides a step-by-step, point-of-care process for assessing, evaluating, treating and managing a particular patient problem.
• Rapid Access Guide has been completely revised and updated. More than 300 Rapid Access entries have been included with this revision.

Part01: Principles of Medical Practice

Section I

Humanism and Ethics

  1Introduction to Internal Medicine as a DisciplineWilliam N. Kelley and Joel D. Howell

  2Clinical Medicine, Clinical Ethics and Physician Mark Siegler, Arthur L. Caplan, and Peter A. SingerProfessionalism

Section II

Basic Mechanisms of Health and Disease

   3The Genome Project and Molecular DiagnosisLeslie G. Biesecker, Barbara B. Biesecker, and Francis S. Collins

   4Normal Cell Growth and DifferentiationMax S. Wicha

   5Principles of the Immune ResponseRobert J. Winchester

   6Inflammation: Cells, Cytokines, and Other Zoltan Szekanecz and Alisa E. KochMediators

  7Mechanisms of Hormone ActionDaryl K. Granner

  8Principles of NutritionDavid H. Alpers

  9Principles of the Renal Regulation of Fluids and L. B. Gardner and H. David HumesElectrolytes

10Pulmonary Gas Exchange John J. Marini

11 Vascular Biology Elizabeth Nabel

12 Disorders of Lipid Metabolism Daniel J. Rader

13 Pathogenesis of Atherosclerosis Alan M. Fogelman, Franklin L. Murphy, and Peter A.Edwards

14 Some Functional Pathways in the Central Nervous John A. Kiernan System

15 Biology and Genetics of Aging and Longevity Richard A. Miller

16 Clinical Physiology of Aging Lewis A. Lipsitz

17 Healthcare Implications of an Aging Society Joan Weinryb, Dennis Hsieh, Risa Lavizzo-Mourey

18 Host-Parasite Interaction Herbert L. DuPont and Liliana Rodriguez

19 Etiology of Malignant Disease William A. Blattner

20 Molecular and Cell Biology of Neoplasia Peter C. Nowell

21 Epidemiology of Malignant Disease David Schottenfeld

22 Prevention of Neoplasia Peter Greenwald

23 Transplantation Immunology Judith A. Shizuru

Section III

Approach to Common Primary Care Issues

24 The Periodic Health Evaluation Albert G. Mulley, Jr.

25 Preoperative Medical Evaluation Judi M. Woolger

26 Immunizations Theodore C. Eickhoff

27 Infectious Disease Prevention in the International David O. Freedman Traveler

28 Cancer Screening and Early Detection John K. Gohagan, Barnett S. Kramer, and William C.Black

29 Epidemiology and Prevention of Cardiovascular Lori Mosca Disease

30 Systemic Hypertension Myron H. Weinberger

31 Approaches to Hypercholesterolemia and Other Daniel J. Rader Abnormal Lipid Profiles

32 Approach to the Patient with Chest Pain (Cardiac Alberto A. Mitrani and Non-Cardiac)

33 Smoking and Smoking Cessation Alfred Munzer

34 Approach to the Problem of Alcohol Abuse and Charles P. O'Brien Dependence

35 Approach to the Problem of Substance Abuse Charles P. O'Brien

36 Obesity Albert J. Stunkard and Thomas A. Wadden

37 Anorexia Nervosa and Eating Disorders Paul M. Copeland

38 Approach to the Patient with Unintentional Weight Daniel M. Lichstein and Robert L. Hernandez Loss

39 Depression, Anxiety, and Other Psychiatric Maria Llorente Disorders

40 Care of the Dying Patient Joanne Lynn and Betty Ferrell

Section IV

Principles of Clinical Evaluation

41 The Clinical Approach to the Patient James O. Woolliscroft

42 Principles of Clinical Epidemiology Jay M. Sosenko

43 Evidence-Based Medicine Mark T. O'Connell

44 Computers in Support of Clinical Medicine Edward H. Shortliffe

45 Quality Improvement and Clinical Outcome David J. Shulkin Assessment

46 Assessment of Physician Performance in the Roberta Parillo, Mark Rivo, and L. B. Gardner New Health Care Environment

47 Medical Malpractice and Risk Management Kimberly A. Cook and Juan D. Reyes

Section V

Related Medical Disciplines

48 Adolescent Medicine Gail B. Slap

49 Principles of Occupational Medicine Mark R. Cullen and Linda Rosenstock

50 Medical Ophthalmology Michele R. Piccone and Stuart L. Fine

51 Medical Otolaryngology Erica R. Thaler and David M. Kennedy

52 Principles of Women's Medicine Erin N. Marcus

53 Sports Medicine Paul McCaffrey Ford and Gordon O. Matheson

54 Principles of Rehabilitation Medicine Kresimir Banovac, Debbie Fertel, Joseph Bauerlein

55 Principles of Clinical Pharmacology D. Craig Brater

56 Alternative Medicine: Prevalence, cost, and utility Mark Multach

Section VI

Selected Medical Emergencies

57 General Principles in the Approach to the Patient Sheldon Jacobson With an Acute Emergency

58 Animal Bites and Stings Faith T. Fitzgerald

59 Near Drowning Leonard D. Hudson

60 Treatment of Anaphylaxis Marc S. McMorris

61 Cardiopulmonary Resuscitation Kathleen S. Schrank

62 Hyperthermia and Hypothermia Faith T. Fitzgerald

63 Ionizing Radiation Injuries Brahm Shapiro

Part 02: Cardiology

Section I

Approach to the Patient with Cardiovascular Disorders

64 Essential Features of the Cardiac History and Elizabeth G. Nabel Physical Examination

65 Approach to the Patient with Chest Pain Elizabeth G. Nabel

66 Approach to the Patient with Heart Failure Robert J. Cody

67 Approach to the Patient with Cardiac S. Adam Strickberger, Douglas P. Zipes, and Fred Arrhythmias Morady

68 Approach to the Patient with Heart Murmurs Jonathan Abrams

69 Approach to the Patient with Syncope Patrick T. O'Gara, Kristin Ellison

70 Approach to the Pregnant Patient with Heart G. Michael Felker and Kenneth L. Baughman Disease

71 Approach to the Patient with Hypotension and Todd M. Koelling and Robert J. Cody Shock

Section II

Disorders of the Cardiovascular System

72 Coronary Artery Disease Mihai Gheorghiade and Robert O. Bonow

73 Acute Myocardial Infarction Robert Roberts

74 Myocardial Diseases Michael R. Bristow, John B. O'Connell, and LouisaMestroni

75 Tumors of the Heart Joel S. Raichlen and Martin G. St. John Sutton

76 Cardiac Arrhythmias Bradley P. Knight, Douglas P. Zipes, and Fred Morady

77 Valvular Heart Disease Kim A. Eagle and David Bach

78 Congenital Heart Disease in the Adult Thomas J. Ryan and Kevin Harrison

79 Pericardial Diseases E. William Hancock

80 Pulmonary Hypertension and Cor Pulmonale Lewis J. Rubin

81 Vascular Medicine Mark A. Creager and Marie Gerhard-Herman

82 Genetics of the Cardiovascular System Craig T. Basson and Carl J. Vaughan

Section III

Diagnostic and Therapeutic Modalities in Cardiovascular Diseases

83 Cardiovascular Radiology Robert D. Tarver, Dewey J. Conces, Jr., Lynn S.

Broderick

84 Electrocardiography, Exercise Stress Testing, and Charles Fisch Ambulatory Monitoring

85 Echocardiography William F. Armstrong

86 Radionuclide and Magnetic Resonance Mark A. Lawson and Gerald M. Pohost Techniques

87 Diagnostic and Therapeutic Catheterization Richard A. Lange and L. David Hillis

88 Electrophysiologic Testing Fred Morady

89 Principles of Cardiac Conditioning and Jonathan N. Myers and Victor F. Froelicher Rehabilitation

90 Clinical Pharmacology of Cardiovascular Drugs D. Craig Brater

91 Use of Anticoagulant Drugs Michael D. Ezekowitz

92 Principles and Applications of Cardiac Surgery