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Table of Contents:

Contributing Authors
Preface
1 Historical Background of Discoid and Systemic Lupus Erythematosus 3
2 Definition, Classification, Activity, and Damage Indices 19
3 The Role of Environment in Systemic Lupus Erythematosus and Associated Disorders 33
4 The Epidemiology of Systemic Lupus Erythematosus 65
5 An Overview of the Pathogenesis of Systemic Lupus Erythematosus 87
6 The Genetics of Human Lupus 97
7 The Genetics of Murine Systemic Lupus Erythematosus 121
8 Apoptosis 145
9 T Lymphocytes, Natural Killer Cells, and Immune Regulation 157
10 Cytokines in the Pathogenesis of Systemic Lupus Erythematosus 187
11 B-Cell Abnormalities in Systemic Lupus Erythematosus 205
12 Abnormalities in Immune Complex Clearance and Fc[gamma] Receptor Function 219
13 Complement and Systemic Lupus Erythematosus 243
14 Mechanisms of Acute Inflammation and Vascular Injury in Systemic Lupus Erythematosus 261
15 Idiotypes and Idiotype Networks 281
16 The Importance of Sex Hormones in Systemic Lupus Erythematosus 307
17 Neuroendocrine Immune Interactions: Principles and Relevance to Systemic Lupus Erythematosus 319
18 Animal Models of Systemic Lupus Erythematosus 339
19 The Structure and Derivation of Antibodies and Autoantibodies 391
20 Antinuclear Antibodies: An Overview 415
21 Antibodies to DNA 425
22 Antibodies to Histone and the Role of the Nucleosome 447
23 Antibodies to Ro/SSA and La/SSB 467
24 Anti-snRNP Antibodies 481
25 The Lupus Anticoagulant and Antiphospholipid Antibodies 495
26 Autoantibodies, Autoantigens, and Nervous System 509
27 Other Serologic Abnormalities in Systemic Lupus Erythematosus 523
28 Pathomechanisms of Cutaneous Lupus Erythematosus 549
29 Cutaneous Manifestations of Lupus Erythematosus 573
30 The Clinical Presentation of Systemic Lupus Erythematosus 621
31 The Musculoskeletal System 629
32 Cardiovascular Manifestations of Systemic Lupus Erythematosus 645
33 Pulmonary Manifestations of Systemic Lupus Erythematosus 663
34 Selected Cutaneovascular Manifestations of Systemic Lupus Erythematosus 685
35 Systemic Lupus Erythematosus and the Nervous System 693
36 Psychopathology in the Patient With Lupus 739
37 Head and Neck Findings in Systemic Lupus Erythematosus: Sjogren's Syndrome and the Eye, Ear, and Larynx 775
38 Hematologic and Lymphoid Abnormalities in Systemic Lupus Erythematosus 793
39 The Use of Exogenous Estrogens, Endocrine System, and Urogenital Tract 821
40 Gastrointestinal and Hepatic Manifestations 843
41 Systemic Lupus Erythematosus in Childhood and Adolescence 863
42 Drug-Induced Lupus 885
43 Infections in Systemic Lupus Erythematosus 917
44 Serum and Plasma Protein Abnormalities and Other Clinical Laboratory Determinations in Systemic Lupus Erythematosus 927
45 Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus 939
46 Differential Diagnosis and Disease Associations 959
47 The Mother in Systemic Lupus Erythematosus 985
48 The Fetus in Systemic Lupus Erythematosus 1023
49 The Neonatal Lupus Syndrome 1041
50 Lupus Nephritis: Pathology, Pathogenesis, Clinical Correlations, and Prognosis 1061
51 Clinical and Laboratory Features of Lupus Nephritis 1077
52 Clinical and Management Aspects of the Antiphospholipid Antibody Syndrome 1093
53 Principles of Therapy and Local Measures 1131
54 Salicylate and Nonsteroidal Therapy 1141
55 Antimalarial Therapies 1149
56 Systemic Glucocorticoid Therapy in Systemic Lupus Erythematosus 1173
57 Immunosuppressive Drug Therapy 1195
58 Nonpharmacologic Therapeutic Modalities 1219
59 Occasional, Innovative, and Experimental Therapies 1229
60 Adjunctive Measures and Issues: Allergies, Antibiotics, Vaccines, Osteoporosis, and Disability 1243
61 Prognosis, Mortality, and Morbidity in Systemic Lupus Erythematosus 1255
62 Experimental Therapies in Systemic Lupus Erythematosus 1275
App. I Patient's Guide to Lupus Erythematosus 1287
App. II Lupus Resources for Patients, Physicians, and Health Professionals 1299
Subject Index 1309