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Table of Contents:

Contributing Authors
Preface
1 Childhood Cancer: Incidence, Survival, and Mortality 1
2 Epidemiologic Research Methods and Childhood Cancer 13
3 Childhood Cancer and Heredity 21
4 Molecular Basis of Childhood Cancer 45
5 Biology of Childhood Cancer 89
6 Tumor Immunology and Pediatric Cancer 121
7 Clinical Assessment and Differential Diagnosis of the Child with Suspected Cancer 149
8 Molecular Pathology of Pediatric Malignancies 161
9 Imaging Studies in the Diagnosis and Management of Pediatric Malignancies 205
10 General Principles of Chemotherapy 237
11 Evolving Molecular and Targeted Therapies 309
12 General Principles of Surgery 351
13 General Principles of Radiation Oncology 369
14 Principles of Immune and Cellular Therapy 381
15 Infants and Adolescents with Cancer: Special Considerations 409
16 Stem Cell Transplantation in Pediatric Oncology 429
17 Gene Transfer and the Treatment of Pediatric Malignancy 453
18 Cancer Clinical Trials: Design, Conduct, Analysis, and Reporting 465
19 Acute Lymphoblastic Leukemia 489
20 Acute Myelogenous Leukemia 545
21 Chronic Leukemias of Childhood 591
22 Myeloproliferative and Myelodysplastic Disorders 615
23 Hodgkin's Disease 637
24 Malignant Non-Hodgkin's Lymphomas in Children 661
25 Lymphoproliferative Disorders and Malignancies Related to Immunodeficiencies 707
26 Histiocytoses 733
27 Tumors of the Central Nervous System 751
28 Retinoblastoma 825
29 Tumors of the Liver 847
30 Renal Tumors 865
31 Neuroblastoma 895
32 Rhabdomyosarcoma and the Undifferentiated Sarcomas 939
33 Ewing's Sarcoma Family of Tumors: Ewing's Sarcoma of Bone and Soft Tissue and the Peripheral Primitive Neuroectodermal Tumors 973
34 Other Soft Tissue Sarcomas of Childhood 1017
35 Osteosarcoma 1051
36 Germ Cell Tumors 1091
37 Endocrine Tumors 1115
38 Management of Infrequent Cancers of Childhood 1149
39 Oncologic Emergencies 1177
40 Hematologic Supportive Care and Hematopoietic Cytokines 1205
41 Infectious Complications in Pediatric Cancer Patients 1239
42 Nutritional Supportive Care 1285
43 Symptom Management in Supportive Care 1301
44 Nursing Support of the Child with Cancer 1333
45 Rehabilitation of the Child with Cancer 1351
46 Psychiatric and Psychosocial Support for the Child and Family 1365
47 The Other Side of the Bed: What Caregivers Can Learn from Listening to Patients and Their Families 1393
48 Ethical Considerations in Pediatric Oncology 1411
49 Late Effects of Childhood Cancer and Its Treatment 1431
50 Educational Issues for Children with Cancer 1463
51 Care of the Dying Child 1477
52 Financial Issues in Pediatric Cancer 1495
53 Pediatric Cancer: Advocacy, Insurance, Education, and Employment 1511
54 Complementary and Alternative Medical Therapies in Pediatric Oncology 1527
55 Pediatric Oncology in Countries with Limited Resources 1541
56 Preventing Cancer in Adulthood: Advice for the Pediatrician 1553
57 Resources for Children with Cancer, Their Families, and Physicians 1565
Subject Index 1629