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Table of Contents:

Contributing Authors
Preface
1 Introduction - The History of Renal Immunopathology 1
Sect. I Process-Related Pathophysiology 13
2 Normal Immune Responses 15
3 Immunopathogenesis of Renal Diseases - An Overview 47
4 Pathophysiology of Progressive Renal Disease 55
5 Mechanisms of Renal Fibrogenesis 73
Sect. II The Immune Response and Renal Injury 103
6 Immunogenics of Renal Disease 105
7 Immunologic Tolerance and the Induction of Autoimmunity 139
8 Renal Expression of MHC Antigens 171
9 Antigen Presentation by Renal Parenchyma: Protection or Promotion from Renal Injury 195
10 Nephritogenic Antigens in the Cellular or Extracellular Membrane 207
11 Pathophysiology of Acute Immune Injury 225
12 Development and Expression of Nephritogenic T Cells 241
13 Molecular Structure and Expression of Nephritogenic Autoantibodies 257
14 Mechanisms of Immune Complex Formation and Deposition in Renal Structures 277
15 Apoptosis in Acute Renal Inflammation 297
16 Mechanisms of Allograft Rejection 321
Sect. III Mediation of Immune Renal Injury 345
17 Glomerular Injury Due to Antibody Alone 347
18 Complement and Complement Regulatory Proteins in Renal Disease 367
19 Proteases and Oxidants in Glomerular Injury 395
20 Growth Factors and Cytokines 415
21 Endothelin and Nitric Oxide 465
22 Eicosanoids 489
23 Coagulation and Thrombosis in Immunologic Renal Diseases 511
24 Chemoattractants and Chemokines in Renal Disease 521
25 Leukocyte Adhesion 551
26 Neutrophils 579
27 Platelets 593
28 Macrophages in Immune Renal Injury 609
29 The Formation of Glomerular Crescents 633
30 Glomerular Mesangial Cells 657
31 The Glomerular Podocyte 693
Sect. IV Animal Models of Immunologic Renal Diseases 709
32 Immune Models of Glomerular Injury 711
33 Immune Models of Tubulointerstitial Injury 779
34 Clinical Evaluation and Management of Hematuria and Proteinuria 815
35 Morphologic Evaluation of Immune Renal Disease 845
36 Interpretation of Clinical Studies of Renal Disease 871
37 Postinfectious Glomerulonephritis 899
38 Immunoglobulin A Nephropathy 931
39 Anti-Glomerular Basement Membrane Disease 949
40 Minimal-Change Nephrotic Syndrome 969
41 Mesangioproliferative Disease 987
42 Focal Segmental Glomerulosclerosis 1001
43 Membranous Nephropathy 1029
44 Systemic Lupus Erythematosus 1057
45 Renal Vasculitis 1105
46 Henoch-Schonlein Purpura 1127
47 Idiopathic Membranoproliferative Glomerulonephritis 1141
48 Amyloidosis, the Dysproteinemias, and Immunotactoid Glomerulopathy 1155
49 Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura and Anti-Phospholipid Antibody Syndromes 1173
50 Clinical and Immunopathogenic Aspects of Human Immunodeficiency Virus-Associated Renal Diseases 1203
51 Recurrent and De Novo Glomerular Disease in Renal Transplants 1225
52 Secondary Glomerulonephridities 1247
53 Acute Interstitial Nephritis 1269
Subject Index 1283