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Ch. 1 Disorders of Water, Electrolytes, and Acid-Base
Disorders of Sodium Balance 7
Diseases of Potassium Metabolism 13
Divalent Cation Metabolism: Magnesium 19
Divalent Cation Metabolism: Calcium 21
Disorders of Acid-Base Balance 25
Disorders of Phosphate Balance 34
Ch. 2 Acute Renal Failure
Causes and Prognosis 39
Renal Histopathology, Urine Cytology, and Cytopathology of Acute Renal Failure 45
Acute Renal Failure in the Transplanted Kidney 47
Renal Injury Due To Environmental Toxins, Drugs, and Contrast Agents 49
Diagnostic Evaluation of the Patient with Acute Renal Failure 55
Pathophysiology of Ischemic Acute Renal Failure 58
Pathophysiology of Nephrotoxic Acute Renal Failure 66
Cellular Features of Injury and Repair 68
Molecular Responses and Growth Factors 70
Nutrition and Metabolism in Acute Renal Failure 74
Supportive Therapies 78
Ch. 3 Glomerulonephritis and Vasculitis
Normal Vascular and Glomerular Anatomy 87
The Primary Glomerulopathies 88
Heredofamilial and Congenital Glomerular Disorders 94
Infection-Associated Glomerulopathies 96
Vascular Disorders 98
Ch. 4 Tubulointerstial Disease
Renal Interstitium and Major Features of Chronic Tubulointerstitial Nephritis 101
Urinary Tract Infection 106
Reflux and Obstructive Nephropathy 112
Cystic Diseases of the Kidney 119
Toxic Nephropathies 124
Metabolic Causes of Tubulointerstitial Disease 127
Renal Tubular Disorders 129
Ch. 5 Hypertension and the Kidney
The Kidney in Blood Pressure Regulation 135
Renal Parenchymal Disease and Hypertension 140
Renovascular Hypertension and Ischemic Nephropathy 144
Adrenal Causes of Hypertension 148
Insulin Resistance and Hypertension 151
The Role of Hypertension in Progression of Chronic Renal Disease 153
Pharmacologic Treatment of Hypertension 156
Hypertensive Crises 162
Ch. 6 Transplantation as Treatment of End-Stage Renal Disease
Histocompatibility Testing and Organ Sharing 171
Transplant Rejection and Its Treatment 173
Posttransplant Infections 176
Immunosuppressive Therapy and Protocols 181
Evaluation of Prospective Donors and Recipients 183
Medical Complications of Renal Transplantation 185
Technical Aspects of Renal Transplantation 187
Kidney-Pancreas Transplantation 189
Transplantation in Children 191
Recurrent Disease in the Transplanted Kidney 194
Ch. 7 Dialysis as Treatment of End-Stage Renal Disease
Principles of Dialysis: Diffusion, Convection, and Dialysis Machines 201
Dialysate Composition in Hemodialysis and Peritoneal Dialysis 203
High-Efficiency and High-Flux Hemodialysis 204
Principles of Peritoneal Dialysis 206
Dialysis Access and Recirculation 211
The Dialysis Prescription and Urea Modeling 212
Complications of Dialysis 215
Ch. 8 Systemic Diseases and the Kidney
Diabetic Nephropathy: Impact of Comorbidity 219
Vasculitis 220
Amyloidosis 223
Sickle Cell Disease 226
Renal Involvement in Malignancy 230
Renal Involvement in Tropical Diseases 238
Renal Disease in Patients with Hepatitis and HIV 241
Renal Involvement in Sarcoidosis 246
Renal Involvement in Essential Mixed Cryoglobulinemia 247
Kidney Disease and Hypertension in Pregnancy 249
Renal Involvement in Collagen Vascular Diseases and Dysproteinemias 253
Index 261
Color Plates 271