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Table of Contents:

Contributing Authors
Preface
Color Plates follow p. xviii
1 Examination of the Blood and Bone Marrow 3
2 Clusters of Differentiation 27
3 Clinical Flow Cytometry 99
4 Cytogenetics 131
5 Molecular Biology and Hematology 153
6 Origin and Development of Blood Cells 169
7 Erythropoiesis 195
8 The Mature Erythrocyte 217
9 Destruction of Erythrocytes 249
10 Neutrophilic Leukocytes 267
11 The Human Eosinophil 311
12 Basophilic Leukocytes: Mast Cells and Basophils 335
13 Mononuclear Phagocytes 349
14 Phagocytosis 387
15 Lymphocytes and Lymphatic Organs 409
16 B Lymphocytes 439
17 T Lymphocytes and Natural Killer Cells 475
18 Effector Mechanisms in Immunity 527
19 Megakaryocytes and Platelets 605
20 Platelet Function in Hemostasis and Thrombosis 651
21 Blood Coagulation and Fibrinolysis 677
22 Endothelium: Angiogenesis and the Regulation of Hemostasis 775
23 Red Cell, Platelet, and White Cell Antigens 791
24 Transfusion Medicine 831
25 Hematopoietic Stem Cell Transplantation 883
26 Gene Therapy for Hematologic Disorders, Human Immunodeficiency Virus Infection, and Cancer 911
27 Anemia: General Considerations 947
28 Iron Deficiency and Related Disorders 979
29 Sideroblastic Anemias 1011
30 Hemochromatosis 1035
31 Porphyria 1057
32 Hereditary Spherocytosis and Other Anemias Due to Abnormalities of the Red Cell Membrane 1089
33 Hereditary Hemolytic Anemias Due to Enzyme Disorders 1115
34 Mechanisms of Immune Destruction of Erythrocytes 1141
35 Autoimmune Hemolytic Anemias 1157
36 Alloimmune Hemolytic Disease of the Fetus and Newborn 1183
37 Paroxysmal Nocturnal Hemoglobinuria 1203
38 Acquired Nonimmune Hemolytic Disorders 1223
39 Abnormal Hemoglobins: General Principles 1247
40 Sickle Cell Anemia and Other Sickling Syndromes 1263
41 Unstable Hemoglobin Disease 1313
42 Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis 1319
43 Megaloblastic Anemias: Disorders of Impaired DNA Synthesis 1367
44 Acquired and Inherited Aplastic Anemia Syndromes 1397
45 Red Cell Aplasia 1421
46 Congenital Dyserythropoietic Anemias 1439
47 Anemias Secondary to Chronic Disease and Systemic Disorders 1445
48 Anemias Unique to Pregnancy and the Perinatal Period 1467
49 Hemoglobins Associated with Cyanosis: Methemoglobinemia and Low-Affinity Hemoglobins 1487
50 Erythrocytosis 1495
51 Diagnostic Approach to the Bleeding Disorders 1511
52 Thrombocytopenia: Pathophysiology and Classification 1529
53 Thrombocytopenia Caused by Immunologic Platelet Destruction 1533
54 Thrombotic Thrombocytopenic Purpura and Other Forms of Nonimmunologic Platelet Destruction 1555
55 Miscellaneous Causes of Thrombocytopenia 1565
56 Bleeding Disorders Caused by Vascular Abnormalities 1573
57 Thrombocytosis 1591
58 Qualitative Disorders of Platelet Function 1603
59 Inherited Coagulation Disorders 1619
60 Acquired Coagulation Disorders 1669
61 Thrombosis and Antithrombotic Therapy 1713
62 Diagnostic Approach to Malignant and Nonmalignant Disorders of the Phagocytic and Immune Systems 1761
63 Neutropenia 1777
64 Qualitative Disorders of Leukocytes 1801
65 Abnormalities of the Monocyte-Macrophage System: Lysosomal Storage Diseases 1819
66 Langerhans Cell Histiocytosis 1827
67 Infectious Mononucleosis and Other Epstein-Barr Virus-Related Disorders 1837
68 Primary Immunodeficiency Syndromes 1863
69 Acquired Immunodeficiency Syndrome 1875
70 Disorders of the Spleen 1893
71 Hematopoietic-Lymphoid Neoplasms: Principles of Diagnosis 1913
72 Complications of Hematopoietic Neoplasms 1919
73 Principles and Pharmacology of Chemotherapy 1945
74 Immunotherapy 1971
75 Supportive Care in Hematologic Malignancies 1997
76 Molecular Genetics of Acute Leukemia 2045
77 Classification and Differentiation of the Acute Leukemias 2063
78 Acute Lymphoblastic Leukemia in Adults 2077
79 Acute Myeloid Leukemia in Adults 2097
80 Acute Lymphoblastic Leukemia in Children 2143
81 Acute Myelogenous Leukemia in Children 2169
82 Acute Promyelocytic Leukemia 2191
83 Myelodysplastic Syndromes 2207
84 Chronic Myeloid Leukemia 2235
85 Polycythemia Vera 2259
86 Myelofibrosis 2273
87 Systemic Mastocytosis 2285
88 Diagnosis and Classification of Non-Hodgkin Lymphomas 2301
89 Molecular Aspects of Non-Hodgkin Lymphomagenesis 2325
90 Non-Hodgkin Lymphomas in Adults 2363
91 Non-Hodgkin Lymphomas in Children 2411
92 Chronic Lymphocytic Leukemia 2429
93 Hairy Cell Leukemia 2465
94 Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sezary Syndrome 2485
95 Hodgkin Disease 2521
96 Practical Aspects of the Clinical Approach to Patients with Monoclonal Immunoglobulin Disorders 2555
97 Monoclonal Gammopathy of Undertermined Significance and Smoldering Multiple Myeloma 2565
98 Multiple Myeloma 2583
99 Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis) 2637
100 Waldenstrom Macroglobulinemia 2667
101 Cryoglobulinemia, Heavy Chain Diseases, and Monoclonal Gammopathy-Associated Disorders 2683
App. A Normal Blood and Bone Marrow Values in Humans 2697
App. B Comparative Hematology 2707
Index