Carnitine System: A New Therapeutical Approach to Cardiovascular Diseases, Vol. 162

Author: Jan Willem Jong
Published: June 1995
Publisher: Kluwer Academic Publishers
ISBN: 0792333187
Hardcover Book
Number of Pages: 400

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In the last few years, derivatives of L-carnitine, such as acetyl-L- carnitine and propionyl-L-carnitine, have been made available to doctors for treatment of specific pathologies. This treatise focuses on experimental and clinical aspects of the carnitine family and cardiovascular diseases, for clinicians and basic scientists. Following an introduction, the volume contains 26 contributed chapters in three parts: the carnitine system in the heart--molecular aspects; therapeutic efficacy of L-carnitine at the myocardial level; and therapeutic efficacy of propionyl-L-carnitine.

Table of Contents
List of Contributors
1 Introduction 1
2 Carnitine-dependent pathways in heart muscle 7
3 Carnitine and carnitine esters in mitochondrial metabolism and function 21
4 The effects of carnitine on myocardial carbohydrate metabolism 39
5 Accumulation of fatty acids and their carnitine derivatives during myocardial ischemia 53
6 Carnitine acylcarnitine translocase in ischemia 69
7 Amphilphilic interactions of long-chain fatty acylcarnitines with membranes: potential involvement in ischemic injury 83
8 Mitochondrial injury in the ischemic-reoxygenated cardiomyocyte: the role of lipids and other pathogenic factors 101
9 Free radical-mediated damage and carnitine esters 123
10 Carnitine transport in volume-overloaded rat hearts 133
11 Myocardial carnitine deficiency in human cardiomyopathy 145
12 Is the carnitine system part of the heart antioxidant network? 169
13 Experimental evidence of the anti-ischemic effect of L-carnitine 183
14 Carnitine metabolism during diabetes and hyperthyroidy 199
15 Carnitine and lactate metabolism 209
16 Therapeutic potential of L-carnitine in patients with angina pectoris 225
17 Carnitine and myocardial infarction 245
18 Cardiac electrophysiology of propionyl-L-carnitine 253
19 Acute vs. chronic treatment with propionyl-L-carnitine: hemodynamic and electrophysiological effects on rabbit heart 261
20 Mechanical recovery with propionyl-L-carnitine 275
21 Dissociation of hemodynamic and metabolic effects of propionyl-L-carnitine in ischemic pig heart 291
22 Effect of propionyl-L-carnitine on rats with experimentally induced cardiomyopathies 307
23 Utilization of propionyl-L-carnitine for the treatment of heart failure 323
24 Hemodynamic and metabolic effect of propionyl-L-carnitine in patients with heart failure 337
25 Carnitine metabolism in peripheral arterial disease 353
26 Effect of propionyl-L-carnitine on experimental models of peripheral arteriopathy in the rat 365
27 Effect of L-carnitine and propionyl-L-carnitine on cardiovascular disease: a summary 383

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