Immunogenetics: Advances and Education the First Congress of the Slovak Foundation, Vol. 35

Author: Alejandro Madrigal
Published: January 1997
Publisher: Kluwer Academic Publishers
ISBN: 0792346130
Hardcover Book
Number of Pages: 265

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This is a report of the proceedings of the NATO Advanced Research Workshop held during the First Congress of the Slovak Foundation in Immunogenetics. The book is a new volume in the NATO series of publications and contains chapters by selected, well recognized experts in immunogenetics/histocompatibility. The stated aim of the workshop was to advance the development of immunogenetics/histocompatibility in Slovakia and other countries of NATO. The book has met the editors' objective in that it provides an up to-date review of selected technical, practical, and theoretical issues in histocompatibility and its application to medicine. This book is most appropriate for transplant physicians, laboratorians, and specialists in autoimmune disease and bone marrow transplantation. Students and residents will find some chapters informative, but substantial background knowledge in histocompatibility is needed to fully appreciate the contents. Immunogeneticists will appreciate the in-depth discussion of some more recent findings. The book is attractive. The text contains clear tables and graphs. Some chapters have illustrations. All of these are adequately described and easily found. References are appropriate and adequate in number. The book is unique in that it presents the practical aspect of histocompatibility from the European perspective. Similarly, the preface containing history of Slovakia should be of interest to those working in the area of heredity and human disease. It is divided in seven sections: laboratory accreditation; HLA diversity; HLA and disease; bone marrow transplantation; HLA and non HLA aspects in transplantation; solid organ and cornea transplantation; and HLAtyping. This is a good book for a medical, research, or clinical laboratory library, and as personal reference material for immunogeneticists, directors of histocompatibility laboratories, and transplant physicians. Comprises the proceedings of the NATO Advanced Research Workshop on the First Congress of Slovak Foundation Education in Immunogenetics held in September 1996 in Bratislava, Slovakia. The 30-some contributions are divided into seven sections: accreditation with European and American histocompatibility immunogenetics organizations; HLA diversity and applications; HLA and diseases; bone marrow transplantation; transplantation, HLA, and non-HLA aspects; solid organ and eye cornea transplantation; and HLA users. The proceedings are introduced with a brief synopsis of Slovakian history describing the glorious Moravian empire from the 5th century onward in charmingly stilted English. A few contributions are written in similarly stilted English, or are studded with typos, although they are by no means impossible to decipher. . Madrigal, Alejandro J. (Royal Free Hospital); Bencova, Margita (Slovak Foundation Education in Immunogenetics); Middleton, Derek (City Hospital, Belfast); Charron, Dominique (Institute des Cordeliers, Paris)The contributors represent the specialties of immunogenetics, transplantation immunology, and experimental therapy. Most are from hospitals, universities, and research institutes in fifteen countries, including the Slovak Republic, Norway, the Netherlands, Poland, Germany, Canada, and Russia. Institutions prominently represented include Slovak Foundation Education in Immunogenetics, Leiden Univ Hospital, Univ of Oslo, Univ of Ulm, Univ of Newfoundland, Univ of Toronto, and Institute for Clinical Immunology-Russia.

Table of Contents
Preface
Acknowledgements
Introduction
Report
Haiku
Organizing Committee
List of Participants
The Slovak Foundation: Education in Immunogenetics 3
Accreditation in Europe 13
Accreditation - A Personal View 21
HLA Diversity of Alleles and Haplotypes. The Contribution of the 12th International Histocompatibility Workshop 27
The Associated Polymorphism of HLA-DR2: Genotyping of DRB1, DRB5, DQB1 loci in Slovakia Caucasian Population 33
Paternity Testing - Past, Present, Future 37
The Molecular Basis of the HLA Association in Celiac Disease. A Model Disease for Type 1 Diabetes and other HLA Associated Disease 61
Immunogenetics of Graves' Disease - An Overview 71
Assessing Prognosis in Rheumatoid Arthritis Using Monoclonal Antibodies and Flow Cytometry 87
Hashimoto's Thyroiditis and HLA-DR-DQ Haplotypes Associated with Control of Disease Resistance 99
Detection of the Tick Borne Encephalitis Virus in the Ticks and the Study of HLA Associations with the Tick Borne Encephalitis Onset 103
Immunogenetic Prognosis for Susceptibility to the Stomach Cancer Onset 105
Permissible Mismatches, Acceptable Mismatches and Tolerance: New Trends in Decision Making 109
The Application of Cellular Tests in the Selection of Unrelated Donors for Bone Marrow Transplantation 121
HLA Typing at the Molecular Level in the Process of Donor Selection for Bone Marrow Transplantation 135
Bone Marrow Transplantation at Princess Margaret Hospital, University of Toronto 141
Transatlantic Bone Marrow Transplantation 149
The Role of HLA-DR, DQ, DP Subregions Compatibility in the Induction of Cytotoxic T Lymphocytes in Kidney Transplantation from Living Donor 153
Microsatellite Testing of the Major Histocompatibility Complex in Human 159
NCOI Polymorphism within the TNF[alpha] Promotor Region and the First Intron of TNF[beta] Gene in Association with DRB1 Specificities in Healthy Volunteers 163
HLA in Kidney Transplantation 171
Facts and Figures of Eurotransplant 175
Affect of Class I and Class II HLA Groups on Graft and Patient Survivals in Kidney Transplant Patients 193
The First Kidney Transplantation in Slovakia 201
HLA Class I and Class II Matched Donor Material for Improved Corneal Allograft Survival 203
HLA Typing from Serology to Molecular Biology 217
HLA-DP Epitope Typing Using Monoclonal Antibodies 223
Evolution of Molecular HLA Typing 233
Internet Application in the Histocompatibility Laboratory 243
Author's Index 255
Subject Index 257

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