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Table of Contents:
Preface
List of Contributors
New Pharmacokinetic Concepts 1
The Biophase Concept 13
Handedness in Anesthetic Pharmacology 19
Anesthetics and Ventilatory Drive 31
When Does the Infant Mature Pharmacologically? 49
Brain Imaging for Elucidating Mechanisms of Anesthesia 55
Is Pharmacokinetics Relevant? 63
Physiologic vs. Pharmacologic Sleep 71
Awareness under Anesthesia: Current Understanding 77
Depth of Anesthesia Monitoring Techniques: An Overview 85
Bispectral Index Monitoring Technology: An Overview 91
Bispectral Monitoring Technology: Clinical Applications 99
Target Controlled Drug Delivery in Anesthesiology 105
The Principles of Total Intravenous Anesthesia (TIVA) 117
Transmucosal and other New Drug Delivery Technologies 137
A Concept for Assessing Anesthetic Interactions 153
Drug Interactions: Opioids and Sedative Hypnotics 165
Interactions: General Principles 171
Drug Interactions: Opioids and Inhaled Anesthetics 181
An Update on the Clinical use of Propofol 195
Kinetic Considerations in the Selection of an Inhaled Anesthetic 199
Controversies Regarding Sevoflurane & Desflurane Toxicity 207
The Role of Alpha[subscript 2] Agonists in Anesthesiology 213
Current Concepts in Anti-Emetic Therapy 227
New Insights into Muscle Relaxants 233
Remifentanil: Clinical Applications 241
Drug Addiction among Anesthesiologists 263
Antagonism of Anesthetic Effects 267
Economics of Anesthesia Education 277
The Role of Ketamine in Anesthetic Practice 285
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