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List of Contributors
Preface
1 Cardiology approaching the year 2000. A clinician's look at molecular cardiology 1
Pt. 1 Cardiovascular specific gene expression
2 The transcriptional building blocks of the heart 7
3 A cardiac-specific troponin I promoter. Distinctive patterns of regulation in cultured fetal cardiomyocytes, adult heart and transgenic mice 17
4 Mice deficient in muscle LIM protein (MLP) reveal a pathway to dilated cardiomyopathy and heart failure 27
5 Regulation of endothelial cell specific receptor tyrosine kinase gene expression during development and disease 35
6 Smoothelins: one gene, two proteins, three muscle cell types .... so far 49
Pt. 2 Transcription regulation
7 Regionalization of transcriptional potential in the myocardium: 'cardiosensor' transgenic mice 67
8 Human troponin genes: transcriptional regulation and chromosomal organization 75
9 Retinoid signaling: insight from genetically engineered mice 87
10 Ventricular expression of the atrial regulatory myosin light chain gene 99
11 Expression of rat gap junction protein connexin 40 in the heart 117
Pt. 3 Ion channels and gap junction
12 Sympathetic regulation of cardiac delayed rectification: relationship to cardiac arrhythmias 125
13 The sarco(endo)plasmic reticulum Ca[superscript 2+] pumps in the cardiovascular system 139
14 Potassium channels; genes, proteins, and patients 151
15 Expression of Cx43 in cardiac and aortic muscle cells of hypertensive rats 161
16 Genetic engineering and cardiac ion channels 171
Pt. 4 Intracellular signaling
17 Receptor tyrosine kinase signaling in vasculogenesis and angiogenesis 179
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