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Table of Contents:

Some keys to the literature
Contributing authors
Preface, first edition
Preface, second edition
Preface, third edition
Preface, fourth edition
1 Historical aspects of diabetes and diabetic renal disease 1
2 The nature of the diabetic glomerulus: pressure-induced and metabolic aberrations 7
3 Definition of diabetic renal disease in insulin-dependent diabetes mellitus based on renal function tests 17
4 Retinopathy in relation to albuminuria and blood pressure in IDDM 31
5 Microalbuminuria and cardiovascular disease 39
6 The heart in diabetes: results of trials 51
7 Albuminuria in non-insulin-dependent diabetes - renal or extra renal disease? 61
8 The clinical course of renal disease in Caucasian NIDDM-patients 73
9 Use of albumin/creatinine ratio in patient care and clinical studies 85
10 Serum creatinine and other measures of GFR in diabetes 97
11 Familial factors in diabetic nephropathy 103
12 Genetics and diabetic nephropathy 113
13 The concept of low birth weight and renal disease 123
14 Effect of insulin on the kidney and the cardiovascular system 131
15 Diabetes, hypertension, and kidney disease in the PIMA indians 141
16 Value of screening for microalbuminuria in people with diabetes as well as in the general population 151
17 Incidence of nephropathy in IDDM as related to mortality. Cost and benefits of early intervention 163
18 Measurement of albumin and other urinary proteins in low concentration in diabetes mellitus: techniques and clinical significance 171
19 Office tests for microalbuminuria 181
20 Exercise and the kidney in diabetes 191
21 Von Willebrand factor, dysfunction of the vascular endothelium, and the development of renal and vascular complications in diabetes 199
22 Smoking and diabetic nephropathy 209
23 Light microscopy of diabetic glomerulopathy: the classic lesion 217
24 Renal ultrastructural changes in microalbuminuric IDDM-patients 227
25 Renal structure in non insulin-dependent diabetic patients with micro-albuminuria 237
26 Sodium-hydrogen antiport, cell function and susceptibility to diabetic nephropathy 249
27 Advanced glycation end-products and diabetic renal disease 257
28 Protein kinase C in diabetic renal involvement, the perspective of inhibition 263
29 Biochemical aspects of diabetic nephropathy 269
30 The Steno hypothesis and glomerular basement membrane biochemistry in diabetic nephropathy 281
31 Volume homeostasis and blood pressure in diabetic states 289
32 Pathogenesis of diabetic glomerulopathy: the role of glomerular hemodynamic factors 297
33 The role of growth hormone, insulin-like growth factors, epidermal growth factor and transforming growth factor-[beta] in diabetic kidney disease: An update 307
34 Transforming growth factor beta and other cytokines in experimental and human diabetic nephropathy 321
35 Blood pressure elevation in diabetes: the results from 24-h ambulatory blood pressure recordings 335
36 Lipidaemia and diabetic renal disease 357
37 Microalbuminuria in young patients with type 1 diabetes 371
38 Early renal hyperfunction and hypertrophy in IDDM patients including comments on early intervention 383
39 ACE-inhibition and angiotensin II receptor blockade, and diabetic nephropathy 393
40 The concept of incipient diabetic nephropathy and effect of early antihypertensive intervention 399
41 Clinical trials in overt diabetic nephropathy 409
42 Antihypertensive treatment in NIDDM, with special reference to abnormal albuminuria 419
43 The course of incipient and overt diabetic nephropathy: the perspective of more optimal insulin treatment 435
44 Non-glycaemic intervention in diabetic nephropathy: the role of dietary protein intake 443
45 Microalbuminuria and diabetic pregnancy 455
46 Diabetic nephropathy and pregnancy 463
47 Evolution worldwide of renal replacement therapy in diabetes 475
48 Haemodialysis in type 1 and type 2 diabetic patients with end stage renal failure 483
49 Continuous ambulatory peritoneal dialysis in uremic diabetics 491
50 Renal transplantation for diabetic nephropathy 525
51 Prevention of diabetic renal disease with special reference to microalbuminuria 547
52 Combination therapy for hypertension and renal disease in diabetes 559
53 Microalbuminuria in patients with essential hypertension. Cardiovascular and renal implications 569
54 A comparison of progression in diabetic and non-diabetic renal disease: similarity of progression promoters 585