Immunology and Liver (Falk Symposium, #114): Proceedings of the 70th Falk Symposium Held in Basel, Switzerland, October 18-20, 1992

Author: M. P. Manns
Published: August 1993
Publisher: Kluwer Academic Publishers
ISBN: 0792388305
Hardcover Book
Number of Pages: 395

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Increasing knowledge of the immune system has facilitated a deeper insight into the aetiology and pathogenesis of numerous diseases, which already influences the clinician's daily work. Immunology is of particular relevance for inflammatory liver diseases. This book reviews the latest progress in this area. The emphasis is on virus-induced liver diseases as well as on the main groups of autoimmune liver diseases: autoimmune chronic active hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis. Also discussed is the contribution of the immune system to liver cell destruction and chronicity of viral infections including the latest discoveries on hepatitis C and the application of cytokines in the treatment of chronic hepatitis. Significant progress has been made in autoimmune liver diseases concerning the identification and characterization of autoantigens. Furthermore new therapeutic strategies have been developed in autoimmune liver diseases such as ursodeoxycholic acid in primary biliary cirrhosis.

Table of Contents
Introduction
List of Principal Contributors
1 Production and persistence of antigenic peptide/MHC class II complexes in human antigen-presenting cells 3
2 Accessory molecules in T lymphocyte activation by antigens and by superantigens 9
3 The humoral immune response to hepatitis B virus 17
4 Role of immunological tolerance in chronic hepatitis B infection 26
5 Cellular immune reactions to hepatitis B core antigen 39
6 Cellular immune reactions to hepatitis B envelope antigens 48
7 Immunology of hepadnavirus infection in woodchucks 52
8 Genetic variability of hepatitis B virus: potential clinical implications 61
9 Immunopathogenesis of hepatitis A virus infection 85
10 T-lymphocyte response to hepatitis C virus 90
11 Immunopathology of hepatitis C 96
12 Immunology and autoimmunity in hepatitis C
13 Clonal analysis of human lymphocyte-B responses to hepatitis C virus structural and non-structural regions 105
14 Actions of cytokines on immune response and virus replication - an overview 117
15 Innovative therapies for chronic hepatitis B 120
16 The role of interferon-[alpha] in virus elimination: viral inhibitors resulting in persistent infection 131
17 Immunoprotection, immunopathology or tolerance - a question of balance 139
18 Autoantibodies as diagnostic markers, probes in cell biology and reporters of cellular activation 145
19 Applications of molecular biology to the analysis of autoantigens 152
20 Immunological derangements in autoimmunity 166
21 Clinical spectrum and heterogeneity of autoimmune hepatitis: an overview 179
22 Nuclear antigens in autoimmune hepatitis 193
23 Cytoskeleton antibodies in chronic active hepatitis 206
24 Anti-liver cytosol antibodies in hepatology: autoimmune hepatitis, viral hepatitis C and graft-versus-host disease 215
25 The asialoglycoprotein receptor (ASGPR) as hepatic autoantigen 227
26 Autoimmune hepatitis: cellular immune reactions 233
27 Immunogenetics of autoimmune chronic active hepatitis 240
28 Therapy of idiopathic autoimmune chronic active hepatitis 250
29 The cytochrome P450 supergene family: a class of autoantigens 259
30 Cytochrome P450 IID6 in autoimmune hepatitis 269
31 Mechanisms of adverse drug reactions directed against cytochromes P450
32 Identification and characterization of protein adducts of reactive metabolites by the use of specific antibodies 284
33 Advances in primary sclerosing cholangitis 295
34 Immunohistology of primary sclerosing cholangitis 307
35 The immunogenetics of primary sclerosing cholangitis 318
36 Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and ulcerative colitis 324
37 Animal models of sclerosing cholangitis: exploring mechanisms of hepatobiliary inflammation associated with intestinal injury 330
38 Primary biliary cirrhosis: definition and epidemiological features 341
39 Clinical relevance of different types of mitochondrial antibodies in primary biliary cirrhosis 350
40 Molecular basis of mitochondrial autoantigens associated with acyltransferases 361
41 T cell biology and cell surface expression of PDC-E2 in primary biliary cirrhosis 373
42 Immunogenetic influences in primary biliary cirrhosis 383
43 Nuclear autoantibodies in primary biliary cirrhosis 397
44 Animal models of primary biliary cirrhosis 410
45 Disturbed lymphokine production in patients with primary biliary cirrhosis: a functional defect of T lymphocytes? 423
46 Antigen expression and presentation on bile duct epithelium 435
47 Can enterobacterial antigens induce a primary biliary cirrhosis? 447
48 Ursodeoxycholic acid alters hepatocyte membrane structure and function: a therapeutic approach? 459
49 Therapeutic strategies which interfere with the immune system 462
Index 469

Click to compare book prices for Immunology and Liver (Falk Symposium, #114): Proceedings of the 70th Falk Symposium Held in Basel, Switzerland, October 18-20, 1992 Immunology and Liver (Falk Symposium, #114): Proceedings of the 70th Falk Symposium Held in Basel, Switzerland, October 18-20, 1992

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