Adenosine, Cardioprotection, and Its Clinical Application

Author: Robert M. Mentzer
Published: July 1997
Publisher: Kluwer Academic Publishers
ISBN: 0792399544
Hardcover Book
Number of Pages: 239

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Covers all aspects of ischemic preconditioning, including potential mechanisms and clinical applications. Includes papers presented at three symposia. This book is the result of contributions to a series of three symposia on Adenosine, Cardioprotection, and its Clinical Application. The purpose of the book is to provide an updated source of information on adenosine and cardioprotection by leading experts in the field and to guide future experimentation in the area. These objectives are both timely and important, as the current literature on the role of adenosine in cardioprotection is voluminous and sometimes disparate. This book would be of interest to all graduate and medical students, biomedical scientists, and physicians involved in research on a mechanism of cardioprotection and its application to patient care. The editors and contributors are experts in their field. Each chapter presents a concise summary of current knowledge as well as in depth experimental findings. The book covers a wide range of topics extending from whole animal through cellular mechanisms and finally clinical application. As a result, the book provides a comprehensive overview of the field. Further attention to the role of adenosine as protection from ischemic- and reperfusion-induced dysrhythmias would have been useful. Figures of experimental results and flow diagrams are numerous, clearly illustrated, and instructive. The book is an excellent source of references, although the index is not extensive. In my opinion, the overall quality of the book is excellent. It accomplishes its goal of providing an updated source of information about the role of adenosine in cardioprotection and directions for future experimentation. It is an important resource and therefore should be available in medical school libraries and bookstores. The book also wouldbe a valuable addition to the library of those individuals interested in the actions of adenosine on the heart and/or mechanisms of cardioprotection. Examines all aspects of adenosine cardio-protection and ischemic preconditioning, including potential mechanisms and clinical applications. Among the topics are the concept of cardio- protection against myocardial ischemia, preconditioning in human muscle and myocytes, and potassium channel openers and cardiac surgery. The 20 papers are from three symposia for which neither dates nor locations are noted. . Mentzer, Robert M., Jr. (Univ of Kentucky); Kitakaze, Masafumi (Osaka Univ); Downey, James M. (Univ of South Alabama); Hori, Masatsugu (Osaka Univ)The contributors represent the specialties of pathophysiology, pharmacology, toxicology, internal medicine, cardiology, and cardiovascular surgery. Most are from universities, hospitals, and research institutes in the U.S., the U.K., France, and Japan. Institutions prominently represented include Iwate Medical Univ, Osaka Univ, Nihon Univ, Univ of Louisville, and Johns Hopkins.

Table of Contents
Contributing Authors
Preface
Acknowledgements
1 Adenosine and Cardioprotection 3
2 Concept of Cardioprotection Against Myocardial Ischemia 19
3 The Late Phase of Preconditioning Against Myocardial Stunning 29
4 Coronary Perfusion as the Major Determinant of Myocardial Contractility in the Heart: Implication for Myocardial Hibernation 37
5 Myocardial Protection From Reperfusion Injury With Adenosine 49
6 Protein Kinase C - the Key-Enzyme in Ischemic Preconditioning? 73
7 Adenosine, Cardioprotection and Potential Mechanisms 93
8 Activation of Ecto-5'-nucleotidase Mediates Cardioprotection in Ischemic Preconditioning: Important Role of Protein Kinase C 103
9 Role of Mn-SOD Induction in the Second Window Phenomenon of Preconditioning of Ischemic Hearts 115
10 Opioid Receptors, K[subscript ATP] Channels and Ischemic Preconditioning 125
11 Bradykinin and Preconditioning Against Infarction 133
12 Preconditioning in Human Muscle and Myocytes 141
13 Protein Kinase C and Adenosine Synergistically Activate ATP-Sensitive Potassium Currents: Implications for Ischemic Preconditioning 153
14 Adenosine and Myocardial Protection in Humans 167
15 Clinical Applications of Ischemic Preconditioning 177
16 Clinical Pharmacology of Preconditioning and Adenosinergic Drugs 187
17 Clinical Application of Ischemic Preconditioning by ATP-Sensitive Potassium Channel Openers 197
18 Potassium Channel Openers and Cardiac Surgery 203
19 Anti-ischemic Effects of the ATP-sensitive Potassium Channel Opener During Coronary Angioplasty 219
20 Clinical Impact of Ischemic Preconditioning on Infarct Size and Coronary No-reflow Phenomenon after Successful Recanalization in the Acute Myocardial Infarction 225
Index 237

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