Diagnostic and Therapeutic Advances in Pediatric Oncology, Vol. 92

Author: David O. Walterhouse
Published: December 1997
Publisher: Kluwer Academic Publishers
ISBN: 0792399781
Hardcover Book
Number of Pages: 387

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The purpose of Diagnostic and Therapeutic Advances in Pediatric Oncology for the "Cancer Treatment and Research Series" is to provide an up-to-date summary of how recent advances in cancer research are being applied to the care of children with solid tumors. The emphasis of bridging research developments with clinical practice will make this book a unique resource to researchers and clinicians as the application of research developments to clinical practice increases and as clinical observations are studied with modern research tools. Recent advances in the pathogenesis of tumors have increased our understanding of pediatric malignancies. Like never before, the interaction of basic scientists and clinicians promises to improve the quality of care for children with cancer. This book is designed to describe recent discoveries in molecular and developmental biology, current therapy for pediatric solid tumors, and the interaction between laboratory research and clinical care. The purpose is to outline recent discoveries in developmental biology, immunology, and molecular biology and then link them to a clinical context for selected pediatric solid tumors. The target audience is laboratory-based cancer researchers and pediatric oncologists, although pediatric pathologists, radiologists, surgeons, and radiation oncologists would all appreciate the detailed discussion of pediatric solid tumors. This book begins with detailed chapters on developmental biology, immunology, and cancer susceptibility genes, with specific reference to their relationship to pediatric malignancies. The second and third sections cover the most common pediatric embryonal tumors and sarcomas, excluding brain tumors. Each tumor is covered with a variable mixture of biologic and clinical detail. The interplay between laboratory developments and clinical care becomes apparent in each of these chapters. The editors and chapter authors are all recognized experts in the field of pediatric oncology who present comprehensive and current reviews of their respective topics. This is an excellent and timely review that bridges the worlds of laboratory and clinical pediatric oncology research, illustrating the potential interactions between researcher andclinician. For a review of both the biology and clinical care of childhood cancer, this book is a useful tool for all who study or treat pediatric patients with tumors. Summarizes the interface of cancer research with clinical practice in pediatric oncology, showing how recent developments in cancer research are being applied to the care of children with solid tumors. Early chapters describe models for understanding causes of childhood cancer, looking at research evidence supporting roles for involvement of normal developmental regulatory genes in childhood oncogenesis, of abnormal immune regulation, and of heredity. Later chapters describe common forms of solid tumors of childhood outside the central nervous system. A final chapter describes late effects of childhood cancer and therapy and looks at research on understanding and preventing them. For researchers and clinicians. . Walterhouse, David O., MD (Northwestern Univ); Cohn, Susan L., MD (Northwestern Univ)

Table of Contents
Contributors
Preface
I Understanding the Causes of Tumors of Childhood 1
1 Embryonic Development and Pediatric Oncogenesis 3
2 Immunodeficiency States and Related Malignancies 39
3 Familial Cancer Syndromes and Genetic Counseling 63
II Embryonal Tumors 99
4 Molecular Basis of Wilms' Tumor 101
5 Neuroblastoma: Solving a Biologic Puzzle 125
6 Pediatric Germ Cell Tumors 163
7 Hepatic Malignancies in Childhood and Adolescence (Hepatoblastoma, Hepatocellular Carcinoma, and Embryonal Sarcoma) 201
III Sarcomas 213
8 Osteosarcoma 215
9 The Ewing's Sarcoma Family of Tumors: Ewing's Sarcoma and Peripheral Primitive Neuroectodermal Tumor of Bone and Soft Tissue 253
10 Rhabdomyosarcoma: Biology and Therapy 309
IV Late Effects of Childhood Cancer 341
11 Late Effects of Cancer Therapy 343
Index 377

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