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Contributors
Preface
I Functional Correlates of the Architecture of Bone Marrow 1
1 The Architecture of Bone Marrow and Its Role in Hematopoietic Cell Lodgment 2
2 Blood Cell Cytoadhesion Molecules 21
3 Stromal Cells and Clinical Implications 49
II The Interrelationship between Bone Formation and Hematopoiesis 77
4 Relationships and Interactions between Bone and Bone Marrow 79
5 Bone Marrow as a Source of Osteoprogenitor Cells 110
III Stromal Cells and Hematopoietic Growth Factors 125
6 Marrow Stromal Cells: Response to Cytokines and Control of Gene Expression 127
7 Interactions of Hematopoietic Progenitor Cells with Extracellular Matrix 152
IV Hematopoietic Cytoadhesion Molecules 175
8 Hemonectin: A Granulocytic Cytoadhesion Molecule 177
9 The Adhesion of Erythroid Cells to Fibronectin and the Identification of Extracellular Matrix Protein Receptors 190
10 The Role of Thrombospondin in Human Hematopoietic Progenitor Cell Cytoadhesion 206
11 The Molecular Mechanism of Recognition of Intravenously Transplanted Progenitor Cells 217
12 The Role of Proteoglycans in the Adhesion and Differentiation of Hematopoietic Cells 232
V The Clinical Implications of Microenvironmental Defects 247
13 Matrix-Associated Abnormalities in Myeiofibrosis 249
14 The Biology and Use of Long-Term Human Bone Marrow Cultures 266
15 The Role of Physiological Perfusion in the Metabolism and Genetic Regulation of Cytokine Production in Mesenchymal Stromal Cells 283
Index 299