Clinical Hematology and Fundamentals of Hemostasis

Author: Denise M. Harmening
Published: December 2001
Publisher: Davis F A
ISBN: 0803607830
Hardcover Book
Number of Pages: 730

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The book contains predominantly color illustrations, with some black-and-white illustrations. The third edition of this text has been designed as a thorough and concise guide to clinical hematology and fundamentals of hemostasis. The textbook is unique in its five-part format, featuring an introduction to clinical hematology and sections on the anemias, white blood cell disorders, hemostasis / thrombosis, and laboratory methods, allowing easy incorporation into block curricula. New chapter on the use of flow cytometry, the molecular diagnostic techniques in hematopathology, and an introduction to thrombosis and anticoagulant therapy are highlights of this edition. The third edition of this book is an updated guide to clinical hematology and fundamentals of hemostasis, composed of five major parts. The first four parts introduce clinical hematology, hemostasis and thrombosis and describe anemias, white blood cell, vascular, platelet, and clotting factor disorders. The fifth and last part of this textbook describes relevant routine laboratory methods. The purpose is to serve as thorough and concise guide to clinical hematology and fundamentals of hemostasis. There is a need for a brief yet concise reference book and this edition meets the author's objectives. The author states that this book is intended for the medical technologist, hematologist, and practitioner. However, students and novices in the field will find this textbook most useful. Dr. Harmening has been instrumental in many AACLS training programs and a dedicated educator. She is a well-known and respected authority in this field, with numerous publications and contributions. Relevant photographs, diagrams, and schematics, most of them in color and of high quality, aid in the visualization and understanding of the subject matter. Pertinent references are included, although those from the past couple of years are omitted. This is a sufficiently illustrated textbook, with adequate visual aids, tables, and references. The glossary, index, and hematologic reference values on the inside covers contribute to ease of use. The chapter outlines, objectives, case studies, and questions help students in their learning process and in evaluating their understanding of the subject matter. This is a comprehensive and sufficiently thorough overview of clinical hematology and fundamentals ofhemostasis and thrombosis. This book is geared toward medical technologists and students in this field. The fifth part of the book on laboratory methods has been expanded since the previous edition to provide more comprehensive procedures used routinely in the hematology and hemostasis laboratory. A new chapter on molecular diagnostic techniques in hematopathology is also included in this third edition. The updates in the first four parts of this book and the expansion of the fifth part make this a useful textbook as well as a quick reference for students in the areas of hematology and coagulation. Combining the features of text, laboratory procedures manual, and atlas of cell morphology, this volume begins with an introduction to clinical hematology, which is followed by sections on the anemias, white blood cell disorders, hemostasis and thrombosis, and laboratory methods. Fifty-five contributors from various institutions lend their expertise under the editorial guidance of Harmening, who is affiliated with the U. of Maryland at Baltimore. A concise and thorough guide to clinical hematology and the fundamentals of hemostasis. The text's five parts provide a substantial introduction to the subject, followed by sections on the anemias, white blood cell disorders, hemostasis/thrombosis, and laboratory methods. This edition includes new chapters addressing the use of flow cytometry, the molecular diagnostic techniques in hematopathology, and an introduction to thrombosis and anticoagulant therapy. A feature of previous editions, a 260-page color-plate atlas, has been incorporated throughout the text. . Denise M. Harmening, PhD, MT(ASCP), CLS(NCA), Chair and Professor, Department of Medical and Research Technology, School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland

Table of Contents
Preface
Pt. I Introduction to Clinical Hematology 1
1 Morphology of Human Blood and Marrow Cells: Hematopoiesis 1
2 Bone Marrow 39
3 The Red Blood Cell: Structure and Function 58
4 Anemia: Diagnosis and Clinical Considerations 74
5 Evaluation of Cell Morphology and Introduction to Platelet and White Cell Morphology 84
Pt. II Anemias 99
6 Iron Metabolism and Hypochromic Anemias 99
7 Megaloblastic Anemias 112
8 Aplastic Anemia (Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia) 129
9 Introduction to Hemolytic Anemias: Intracorpuscular Defects: I. Hereditary Defects of the Red Cell Membrane 141
10 Hemolytic Anemias: Intracorpuscular Defects: II. Hereditary Enzyme Deficiencies 157
11 Hemolytic Anemias: Intracorpuscular Defects: III. The Hemoglobinopathies 165
12 Hemolytic Anemias: Intracorpuscular Defects: IV. Thalassemia 186
13 Hemolytic Anemias: Extracorpuscular Defects and Acquired Intracorpuscular Defects: V. Paroxysmal Nocturnal Hemoglobinuria 201
14 Anemia Associated with Other Disorders 232
Pt. III White Blood Cell Disorders 251
15 Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis 251
16 Introduction to Leukemia and the Acute Leukemias 272
17 Chronic Leukemia and Related Lymphoproliferative Disorders 301
18 Chronic Myeloproliferative Disorders 331
19 Myelodysplastic Syndromes 358
20 Multiple Myeloma and Related Plasma Cell Disorders 379
21 The Lymphomas 398
22 Lipid (Lysosomal) Storage Diseases and Histiocytosis 425
Pt. IV Hemostasis and Introduction to Thrombosis 441
23 Introduction to Hemostasis 441
24 Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders 471
25 Disorders of Plasma Clotting Factors 495
26 Interaction of the Fibrinolytic, Coagulation, and Kinin Systems: Disseminated Intravascular Coagulation: and Related Pathology 521
27 Introduction to Thrombosis and Anticoagulant Therapy 534
Pt. V Laboratory Methods 563
28 Routine Hematology Methods 563
29 Principles of Automated Differential Analysis 594
30 Applications of Flow Cytometry to Hematology and Hemostasis 615
31 Special Stains/Cytochemistry 641
32 Coagulation 658
33 Molecular Diagnostic Techniques in Hematopathology 682
Answers to Chapter Review Questions 695
Glossary 697
Bibliography 713
Index 717

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