Joint Destruction in Arthritis and Osteoarthritis, Vol. 39

Author: W. B. van den Berg
Published: March 1993
Publisher: Birkhauser Verlag
ISBN: 0817627731
Hardcover Book
Number of Pages: 276

Click to compare book prices for Joint Destruction in Arthritis and Osteoarthritis, Vol. 39

Proceedings of a May 1992 symposium on [title] held in Noordwijkerhout, The Netherlands, by the European Society of Osteoarthrology. Contents are arranged in sections on cartilage destruction, immunopathology, joint loading and cartilage metabolism, cytokines and growth factors, proteases and their inhibitors, therapeutic modulation of destruction, and methodology.

Table of Contents
Cartilage destruction in arthritis and osteoarthritis
Osteoarthritis in the human knee: A dynamic process of cartilage matrix degradation, synthesis and reorganization 3
Experimental arthritis models in the study of the mechanisms of articular cartilage loss in rheumatoid arthritis 15
Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model 27
Mechanisms of cartilage destruction in joint inflammation 49
Immunopathology
Synovial fluid analyses detect and differentiate proteoglycan metabolism in canine experimental models of osteoarthritis and disuse atrophy 63
Humoral and cell-mediated sensitivity to cartilage constituents in mice with antigen-induced arthritis 69
In vitro and in vivo effects of proteoglycan fractions in adjuvant treated rats 75
Are antibodies reactive with chondrocyte proteins enriched in synovial fluids of patients with rheumatoid arthritis? 81
Joint loading and cartilage metabolism
The metabolic response of articular cartilage to abnormal mechanical loading induced by medial or lateral meniscectomy 89
Effects of long-term running exercise on canine femoral head articular cartilage 95
Human and bovine articular cartilage loading measured with a new resistive sensor: Effects of protease degradation and osteoarthritis 101
Cytokines and growth factors
Possible role of IL-1 in arthritis: Effects of prostaglandins in the regulation of IL-1 synthesis and actions 109
Degradative and repair responses of cartilage to cytokines and growth factors occur via distinct pathways 121
Does TGF-[beta] protect articular cartilage in vivo? 127
Human rheumatoid synovial cells (HRSC) in culture express TGF-[beta] receptors and are growth stimulated by the factor 133
Variable TGF-[beta] receptor expression regulates TGF-[beta] responses of articular chondrocytes 139
Proteases and their inhibitors
Proteolytic degradation in human articular cartilage: Its relationship to Stromelysin 149
The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators 161
The role of alpha-1-protease inhibitor (A1PI) in the inhibition of protease activity in human knee osteoarthritis 167
Recombinant human protease nexin-1 prevents articular cartilage-degradation in the rabbit 173
Therapeutic modulation of destruction
In vitro effects of NSAIDs and corticosteroids on the synthesis and secretion of interleukin 1 by human osteoarthritic synovial membranes 181
Animal models of early osteoarthritis: Their use for the evaluation of potential chondroprotective agents 195
The in vivo effects of Naproxen on canine experimental osteoarthritic articular cartilage: Composition, metalloproteinase activities and metabolism 207
Interleukin-1 and Naproxen down-regulate the expression of IL-1 receptors in cultured human rheumatoid synovial cells (HRSC) 213
Effect of Rumalon (glycosaminoglycan-peptide) on the articular tissue 219
Doxycycline protects serum alpha-1-antitrypsin from human neutrophil collagenase
In vitro construction of cells-containing implants for articular cartilage regeneration 231
Cellular aspects on treatment of cartilage injuries 237
Human meniscus transplantation 243
Methodology
In situ hybridisation for Decorin mRNA in rabbit synovium during antigen-induced arthritis 249
Osteoarthritis in rhesus macaques: Assessment of cartilage matrix quality by quantitative magnetic resonance imaging 255
A magnetic resonance imaging study of joint degeneration in the guinea pig knee 261
Development of immortalized human articular cartilage cell lines 267
Subject Index 273

Click to compare book prices for Joint Destruction in Arthritis and Osteoarthritis, Vol. 39 Joint Destruction in Arthritis and Osteoarthritis, Vol. 39

Compare Shop Books - Help - About - Book Links - Book Coupons