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Preface
Contributors
Pt. I Biology of the Allograft Response
1 A Molecular Basis for Transplantation Immunity 1
2 Mechanisms of Cell-Mediated Rejection 33
3 Cytokines: Regulators and Effectors of the Immune Response 59
4 Regulation of Allograft Rejection by Anti-Idiotypic Responses 91
5 Clinical Syndromes Associated with Antibody in Allografts 127
6 Renal Injury and Preservation in Transplantation 149
7 Mechanism of Chronic Rejection 177
8 Xenotransplantation: Potential Opportunity Versus Resistant Challenge 201
9 Histocompatibility and Organ Allocation 251
10 Immunological Tolerance and Its Relationship to Clinical Transplantation 261
Pt. II Diagnosis of Rejection
11 Pathology of Kidney Transplantation 383
12 Fine-Needle Aspiration Cytology 419
13 Sonographic Evaluation of Acute Renal Transplant Rejection 445
Pt. III New Immunosuppressive Agents
14 History and Prospects for Antilymphocyte Antibody Therapy for Tolerance Induction 455
15 Mechanisms of Action of Immunosuppressive Agents: Cyclosporine/FK506/Rapamycin 477
16 Cyclosporine: Clinical Use in Kidney Transplantation 499
17 Tacrolimus and Mycophenolate Mofetil as Primary Immunosuppression for Renal Allograft Recipients 519
18 Newer Immunosuppressive Agents: Mycophenolate Mofetil, Sirolimus, 15-Deoxyspergualin, Brequinar, and Combination Therapy 531
19 Immune Monitoring for Transplant Recipients 563
Pt. IV Systemic Complications of Immunosuppression
20 Cancer in Recipients of Organ Allografts 577
21 Impact of Cytomegalovirus Infection on Renal Transplantation 605
22 Hepatitis in the Renal Allograft Recipient 627
Index 647