Hematopoietic Stem Cell Transplantation

Author: Anthony D. Ho
Published: July 2000
ISBN: 0824702735
Hardcover Book
Number of Pages: 624

Click to compare book prices for Hematopoietic Stem Cell Transplantation

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy—providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC: Ambulatory care and monitoring Regimen-related toxicities Immunodeficiency and immunization Infection Chronic graft-versus-host and disease Secondary malignancies Long-term quality of life Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation. Summarizes current understanding and development of clinical allogeneic HSC transplantation Discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation Considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors Details detection of bone marrow contamination by tumor cells and removal procedures Focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors Explores the effects of growth factor administration and leukapheresis on PB stem cell donors Shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use Reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells Employs automated fluorescence image cytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study, Hematopoietic Stem Cell Transplantation is a blue-chip reference for hematologists, hematopathologists, oncologists, cytotherapists, transplantation immunologists, and molecular biologists.

Table of Contents:

Preface
Contributors
Novel Cytokines and Cellular Components
1 Thrombopoietin: Basic Biology and Clinical Effects 1
2 Preclinical Biology and Potential Clinical Utility of fit3 Ligand 23
3 Stem Cell Factor 31
4 Cytokine Modulation of Hematopoietic Stem Cell Phenotype 47
5 Homing and Self-Renewal of Hematopoietic Stem Cells 69
6 Requirements for Hematopoietic Stem Cell Engraftment and Graft Engineering: Role of Facilitating Cells 87
7 Ins and Outs of Hematopoietic Stem Cells: Regulation by Genes and Stromal Cells 111
8 Cell-Signaling by Adhesion Receptors in Normal and Leukemic Hematopoiesis 125
9 Detection of Infrequent Cells in Blood and Bone Marrow by Flow Cytometry 137
Animal Models
10 Human/Sheep Hematopoietic Chimeras 153
11 Canine Models for Transplantation and Gene Therapy 171
12 Murine Model of In Utero Transplantation 195
CD34+ Selection
13 CD34 Selection Using Immunomagnetic Beads 223
14 Autologous and Allogeneic Transplantation with Blood CD34[superscript +] Cells: A Pediatric Experience 239
15 Using Allogeneic Graft Engineering to Improve Long-Term Survival 251
16 Detection and Significance of Minimal Residual Disease from Solid Tumor Malignancies in Stem Cell Autografts 275
17 Stem Cell Isolation with Immunomagnetic Beads and Tumor Cell Contamination 291
Ex Vivo Expansion
18 CD34 Cell Culture: Clinical Needs and Applications 303
19 Critical Parameters Influencing the Expansion and Differentiation of Cultured Human CD34[superscript +] Cells 321
Advances in Allogeneic Transplantation
20 Mobilization of Peripheral Blood Stem Cells from Normal Donors 333
21 Innovative Approaches for Allogeneic Blood and Marrow Transplantation for Treatment of Hematological Malignancies: Graft Engineering and Nonmyeloablative Preparative Regimens 361
22 Peripheral Blood Stem Cells for Allogeneic Transplantation 383
23 Mechanisms of Cure of Acute Myeloid Leukemia with Allogeneic Transplantation 403
24 Late Complications of Hematopoietic Stem Cell Transplantation 413
25 Prevention of Acute Graft-Versus-Host Disease by Delayed or Selected Lymphocyte Add Back 435
Advances in Autologous Transplantation
26 Blood Stem Cell Versus Bone Marrow Transplantation: A Critical Appraisal 447
27 Autologous Peripheral Blood Stem Cell Collection and Engraftment 457
28 Stem Cell Transplantation for Hodgkin's Disease 479
29 Stem Cell Transplantation for Multiple Myeloma - 10 Years Later 499
30 High-Dose Therapy for Primary and Metastatic Breast Cancer 517
Genetic and Immune Therapy
31 Gene Therapy Using Hematopoietic Stem Cells 537
32 Gene Therapy for Human Immunodeficiency Virus Infection Using Stem Cell Transplantation 553
33 Autografting Followed by Low-Intensity Conditioning Regimen for Allografting 569
34 Development of Retroviral Vectors that Target hematopoietic Stem Cells 575
Index 595

Click to compare book prices for Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cell Transplantation

Compare Shop Books - Help - About - Book Links - Book Coupons