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Series Introduction
Foreword
Preface
Contributors
1 Development of the Atherosclerotic Plaque 1
2 Clinical and Pathological Correlates 51
3 The Role of Inflammation in Plaque Rupture 63
4 Molecular Mechanisms of Plaque Weakening and Disruption 79
5 Epidemiological Evidence for Inflammation in Plaque Rupture 123
6 Role of Mechanical Stress in Plaque Rupture: Mechanical and Biological Interactions 147
7 Determinants of Thrombosis After Plaque Rupture 167
8 The Clinical Manifestations of Plaque Rupture 191
9 Triggers of Coronary Plaque Rupture Syndromes 215
10 Lessons About Plaque Rupture Learned from Angiography 235
11 Intravascular Ultrasonography to Diagnose Vulnerable Plaque 245
12 Detection of Plaque Vulnerability with Intravascular Palpography: Principle and Potentials 269
13 Prospects of Laser Spectroscopy to Detect Vulnerable Plaque 281
14 Optical Coherence Tomography to Assess Plaque Vulnerability 305
15 Magnetic Resonance Imaging of Vulnerable Plaque 321
16 In Vivo Thermography of Coronary Arteries 341
17 Animal Models of Coronary Artery Disease 351
18 Clinical Trial Considerations in the Development of Inhibitors of Cardiovascular Plaque Rupture 367
19 The Relationship Between Cholesterol, Plaque Rupture, and Plaque Stabilization 377
20 Antibiotic Therapy to Stabilize Vulnerable Plaque 399
21 Plaque Sealing: Mechanical Treatment to Stabilize Plaque 429
22 The Potential Role of Serine Proteinase Inhibitors for the Prevention of Plaque Rupture 447
23 Gene Therapy to Stabilize Atherosclerotic Plaque 483
Index 505