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Preface
Contributors
1 Why Endocrine Therapy? 3
2 Tamoxifen and Advanced Breast Cancer: An Overview 17
3 Overview of Aromatase Inhibitors and Inactivators in the Treatment of Advanced Breast Cancer 33
4 Endocrine Treatment of Advanced Breast Cancer: Selective Estrogen-Receptor Modulators (SERMs) 47
5 Other Endocrine and Biological Agents in the Treatment of Advanced Breast Cancer 79
Panel Discussion 1 Advanced Breast Cancer 91
6 Early Breast Cancer: Tamoxifen Overview 125
7 Aromatase Inhibitors and Early Breast Cancer 135
8 SERMs: Overview in Early Breast Cancer 145
9 Surrogate and Intermediate Markers in Early Breast Cancer 157
Panel Discussion 2 Early Breast Cancer 171
10 Neoadjuvant Endocrine Therapy for Breast Cancer: A Medical Oncologist's Perspective 181
11 Neoadjuvant Therapy: Surgical Perspectives 197
12 Pathology of Breast Cancer Following Neoadjuvant Endocrine Therapy 213
13 Neoadjuvant Therapy: Prediction of Response 223
14 Mechanisms of Resistance to Endocrine Therapy 231
Panel Discussion 3 Neoadjuvant Therapy 243
15 Epidemiological Basis of Hormonal Chemoprevention of Breast Cancer 267
16 Breast Carcinogenesis and Its Prevention by Inhibition of Estrogen Genotoxicity 287
17 Use of Selective Antiestrogens for the Chemoprevention of Breast Cancer 303
18 Aromatase Inhibitors and Chemoprevention of Breast Cancer 309
Panel Discussion 4 Chemoprevention 319
Panel Discussion 5 Final Discussion and Wrap-Up 337
Index 365
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