Ocular Oncology A Handbook for Oncologists - Ocular Oncology Retinoblastoma and uveal melanoma represent challenges to both the clinician and basic scientist. There is a need to better understand the molecular biological basis of their pathogenesis, as well as to make earlier diagnoses, improve treatment, and avoid metastasis using the evolving knowledge of the genetic changes at work in these tumors. A timely volume with a unique scientific focus, Ocular Oncology is the only reference to integrate key clinical information with molecular biology and genetic factors triggering and promoting the two most common ocular tumors. Ocular Oncology differs from other texts in oncology and ophthalmology, providing a comprehensive account of the most current basic and clinical science related to eye tumors and offering new ideas about innovative treatments derived from recent genetic, biochemical, and immunological studies. In analyzing over 2000 key sources, more than 40 internationally distinguished contributors track the epidemiology of uveal melanoma and retinoblastoma...patient characteristics and risk factors for tumor growth and metastasis...chromosomal rearrangements and identification of genes conferring tumorigenesis...determinants of tumor phenotype differential gene expression and cellular pathways...immunosuppressive factors and immunotherapy...models of uveal melanoma and retinoblastoma, including genetically engineered mouse models...pathology and patient prognosis...and treatment methods and associated risks for uveal melanoma, intraocular retinoblastoma, and extraocular retinoblastoma. Albert and Polans (both of the Department of Ophthalmology and Visual Sciences, U. of Wisconsin Medical School) present 23 chapters discussing the basic and clinical science related to eye tumors as well treatment options derived from genetic, biochemical, and immunological studies. Current clinical research is reported on and risk and prognostic factors are detailed.