Ocular Oncology

Search for the best prices

on the Internet!

Compare Shop Books - Help - About - Book Links - Book Coupons

ISBN Title/KeyWord/Author

Anesthesiology Books
Cardiology Books
Dermatology Books
Emergency Medicine Books
Endocrinology Books
Geriatrics Books
Gynecology and Obstetrics Books
Hematology Books
Immunology Books
Infectious Diseases Books
Internal Medicine Books
Nephrology Books
Neurology Books
Oncology Books
Ophthalmology Books
Orthopedics Books
Otolaryngology Books
Radiology Books
Sports Medicine Books
Urology Books

Books and Textbooks

Author: Daniel M. Albert
Published: August 2003
Publisher: Marcel Dekker
ISBN: 0824740165
Hardcover Book
Number of Pages: 492

Click to compare book prices for Ocular Oncology

Ocular Oncology

Retinoblastoma and uveal melanoma represent challenges to both the clinician and basic scientist. There is a need to better understand the molecular biological basis of their pathogenesis, as well as to make earlier diagnoses, improve treatment, and avoid metastasis using the evolving knowledge of the genetic changes at work in these tumors. A timely volume with a unique scientific focus, Ocular Oncology is the only reference to integrate key clinical information with molecular biology and genetic factors triggering and promoting the two most common ocular tumors. Ocular Oncology differs from other texts in oncology and ophthalmology, providing a comprehensive account of the most current basic and clinical science related to eye tumors and offering new ideas about innovative treatments derived from recent genetic, biochemical, and immunological studies. In analyzing over 2000 key sources, more than 40 internationally distinguished contributors track the epidemiology of uveal melanoma and retinoblastoma...patient characteristics and risk factors for tumor growth and metastasis...chromosomal rearrangements and identification of genes conferring tumorigenesis...determinants of tumor phenotype -- differential gene expression and cellular pathways...immunosuppressive factors and immunotherapy...models of uveal melanoma and retinoblastoma, including genetically engineered mouse models...pathology and patient prognosis...and treatment methods and associated risks for uveal melanoma, intraocular retinoblastoma, and extraocular retinoblastoma. Albert and Polans (both of the Department of Ophthalmology and Visual Sciences, U. of Wisconsin Medical School) present 23 chapters discussing the basic and clinical science related to eye tumors as well treatment options derived from genetic, biochemical, and immunological studies. Current clinical research is reported on and risk and prognostic factors are detailed.

Table of Contents
Preface
Contributors
1 Clinical Overview of Uveal Melanoma: Introduction to Tumors of the Eye 1
2 Clinical Overview: Retinoblastoma 19
3 Epidemiology of Uveal Melanoma: Patient Characteristics, Risk Factors, and Predisposing Elements 35
4 Epidemiology of Retinoblastoma 47
5 Genetics of Uveal Melanoma: Chromosomal Rearrangements and the Identification of Genes Involved in Tumorigenesis 63
6 Structural Alterations and Gene Expression in the Pathogenesis of Uveal Melanoma 81
7 A Cascade of Genomic Changes Leads to Retinoblastoma 103
8 The Role of the Retinoblastoma Protein in Health, Malignancy, and the Pathogenesis of Retinoblastoma 129
9 Biochemical Pathways: Differential Gene Expression and Cellular Pathways Determining Tumor Phenotype Comparison of Uveal Melanocytes and Uveal Melanoma Cells In Vitro 189
10 p53 and the Molecular Regulation of Cell Fate in Retinoblastoma 211
11 Immunology of Uveal Melanoma: Adaptive Antitumor Immunity and the Basis for Immunotherapy 231
12 Immunology of Uveal Melanoma: Immunosuppressive Factors and the Basis for Immunotherapy 255
13 Models of Uveal Melanoma: Characterization of Transgenic Mice and Other Animal Models for Melanoma 269
14 Using Retinoblastoma Models to Develop New Treatment: Vitamin D Analogues 297
15 Therapy of Uveal Melanoma: Methods and Risk Factors Associated with Treatment 321
16 The Treatment of Retinoblastoma 353
17 Clinical Trials in Uveal Melanoma: Patient Characteristics and the Treatment of Intraocular Tumors 377
18 Clinical Trials in Retinoblastoma 401
19 Pathology of Uveal Melanoma: Histological Parameters and Patient Prognosis 407
20 Retinoblastoma: Pathology and Prognosis 427
21 Molecular Genetics of Retinoblastoma 449
22 Genetically Engineered Mouse Models of Retinoblastoma 465
23 Treatment of Extraocular Retinoblastoma 489
Index 499

Click to compare book prices for Ocular Oncology Ocular Oncology

Compare Shop Books - Help - About - Book Links - Book Coupons