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Series Introduction (Claude Lenfant)
Preface
Contributors
Pt. 1 Epidemiology
1 The Impact of Respiratory Virus Infections on the World's Children 1
2 Respiratory Viruses and Asthma: Epidemiological Considerations in Evaluating Their Association 23
3 Rates of Asthma Exacerbations During Viral Respiratory Infection 45
4 Risk Factors for Wheezing with Viral Upper Respiratory Tract Infections in Children 63
Pt. 2 Pathophysiology and Mechanisms
5 Mechanisms of Virus-Induced Asthma 89
6 The Use of Experimentally Infected Volunteers in Research on the Common Cold 103
7 Overview of Experimental Animal Respiratory Viral Provocation Models 129
8 Role of Allergy and Airway Hyperresponsiveness in Virus-Induced Asthma 155
9 Limitations of Human Experimental Provocation Models for Investigating the Virus-Asthma Link 183
10 Stress, Viral Respiratory Infections, and Asthma 193
Pt. 3 Current and Future Treatments
11 General Virology and Targets for Therapy 209
12 Advances in the Diagnosis of Respiratory Virus Infections 221
13 Current Modalities for Treatment of Respiratory Viruses and Virus-Induced Asthma 245
14 Previously Conducted Trials to Evaluate New Avenues of Therapy 259
Author Index 273
Subject Index 303