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Preface vii
Contributors xiii
Part I. Basic Mechanical Concepts in Cardiopulmonary Physiology 1
1. Pressure-Volume Relationships: Elasticity and Compliance 3
2. Pressure-Flow Relationships: Resistance and Conductance 17
3. Flow Through Collapsible Tubes: Starling Resistors 25
4. Drainage from Compliant Reservoirs 31
5. Work Done by the Heart and Lungs 39
6. The Transport of Substances Across Biological Membranes 45
Appendix 51
References 53
Part II. Physiologic Measurements
7. Principles of Physiologic Measurement 55
8. Measurement of Cardiac Output 67
References 87
Part III. Systemic Circulatory Function 89
9. Cardiac Function: The Basics 91
10. Cardiac Function: Other Concepts 117
11. Cardiac Electrophysiology 133
12. Peripheral Circulatory Function 151
13. Determinants of Arterial Blood Pressure 163
14. Regulation of Blood Flow 171
References 193
Part IV. The Lungs 203
15. The Microcirculation and Pulmonary Edema Formation 205
16. Pulmonary Circulation 225
17. Right Ventricular Function and Cor Pulmonale 239
18. A Physiologic Basis for Mechanical Ventilation 249
19. The Muscles of Respiration 277
20. Pulmonary Gas Exchange 291
References 317
Part V. Clinical Physiology
21. Cardiopulmonary Interactions 333
22. Assessment of Cardiovascular Function in the Critical Care Unit 357
23. Clinical Physiology Rounds in the Critical Care Unit: Case Presentations 381
References 417
Appendix A Common Abbreviations in Critical Care with Some Commonly Used Units 425
Appendix B Hemodynamic and Respiratory Calculations Commonly Used in Critical Care 429
Appendix C Conversion Factors 433
Appendix D Some Useful Approximate Normal Values 435
Index 437