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Preface
Contributors
1 The Interferons: A Clinical Overview 1
Pt. I Target Populations
2 Interferon-Gamma Treatment of Chronic Granulomatous Disease 11
3 Infection Associated with the Surgical Care of the Major Trauma Victim 29
4 Potential Role of Interferon-Gamma in Human Immunodeficiency Virus-Associated Disease 37
5 Interferon-Gamma in the Neonate 53
6 Atopic Dermatitis 67
Pt. II Target Infections
Protozoan Infections
7 The Role of Interferon-Gamma in Resistance Against Toxoplasma gondii 87
8 Leishmaniasis and Interferon-Gamma 123
9 Interferon-Gamma in Trypanosoma cruzi Infections 137
10 Interferon-Gamma and Immunity to Malaria Sporozoites: Implications for the Development of Synthetic Vaccines 159
Viral Infections
11 Interferon-Gamma for Human Papillomavirus Infection 169
12 Herpes Simplex as a Target for Anti-Infective Applications of Interferon-Gamma: Preclinical In Vitro and In Vivo Observations 189
13 The Role of Interferon in Cytomegalovirus Infection 201
14 Interferons and Epstein-Barr Virus Infection 213
Bacterial Infections
15 Treatment of Lepromatous Leprosy with Recombinant Interferon-Gamma 227
16 Interferon-Gamma and the Control of Intracellular Chlamydia Replication 251
17 Influence of Interferon-Gamma on Legionella pneumophila: Mononuclear Phagocyte Interaction 265
Fungal Infections
18 Interferon-Gamma and Fungal Infections 279
Pt. III Target Treatment Strategies
19 Interferon-Gamma as an Adjuvant for Vaccines 295
Index 309
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