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Series Introduction
Preface
Contributors
1 The Structure and Function of Articular Cartilage Matrices 1
2 Heterogeneity of Articular Chondrocytes and Cartilage Matrix 37
3 Growth Plate Structure and Function 67
4 Extracellular Matrix of Cartilage: Collagen 81
5 Extracellular Matrix of Cartilage: Proteoglycans 109
6 Extracellular Matrix of Cartilage: Glycoproteins 139
7 Role of Endogenous Proteinases in the Degradation of Cartilage Matrix 159
8 Role of Physical and Mechanical Agents in Degrading the Matrix 187
9 Role of Crystal Deposition in Matrix Degradation 209
10 Methods for Evaluating Mechanisms of Cartilage Breakdown 225
11 Articular Cartilage Organ Cultures: In Vitro Models of Matrix Homeostasis, Resorption, or Repair 261
12 Degradation of Articular Cartilage in Culture: Regulatory Factors 281
13 Animal Models of Osteoarthritis 347
14 Cartilage Degradation in Animal Models of Inflammatory Joint Disease 385
15 Pathological Cartilage Degradation in Human Arthritides 409
16 Immune Responses to Cartilage Proteoglycans in Inflammatory Animal Models and Human Diseases 435
17 Pharmacological Control of Cartilage Degradation in Osteoarthritis 475
18 Modulation of Cartilage Degradation in Arthritic Diseases by Therapeutic Agents 503
19 Prospects for Medical Intervention in Cartilage Repair 529
Index 547