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Foreword
Preface
I The Challenge of Advanced Renal Cell Carcinoma
1 Overview 3
II Clinical Features of Renal Cell Carcinoma
2 Prognostic Factors in Metastatic Renal Cell Carcinoma 11
3 von Hippel-Lindau Disease: Clinical and Biologic Features 25
III The Molecular Biology of Renal Cell Carcinoma
4 Molecular Studies of Sporadic and Familial Renal Cell Carcinoma 33
5 Oncogenes in Renal Cell Carcinoma 43
6 Oncogene-Induced Transformation of Human Kidney Proximal Tubule Cells 53
7 Targeted Bispecific Antibody-Dependent Cellular Cytotoxicity Against Renal Cancer 67
8 Gene Therapy in the Treatment of Murine Renal Cell Cancer 77
9 Antiproliferative and Antitumor Effect of Interferon-[alpha] Renal Cell Carcinoma: Correlation with the Expression of a Kidney-Associated Differentiation Glycoprotein 85
IV Cell-Mediated Immune Responses and Adoptive Immunotherapy
10 Natural Killer Cells in Human Renal Cell Carcinoma 95
11 Overview of Specific T Cell Therapy 107
12 Characterization of Tumor-Infiltrating Lymphocyte Lines Derived from Renal Cell Carcinoma: Demonstration of T Cells That Display Either Specific or Selective Response to Tumor 115
13 Tumor-Infiltrating Lymphocytes in Metastatic Renal Cell Carcinoma: The Cleveland Clinic Experience
14 Adoptive Immunotherapy of Disseminated Renal Cell Cancer: European Experience and Perspective 139
15 Adoptive Immunotherapy for Renal Cell Carcinoma Using Cytokine-Modulated Tumor-Infiltrating Lymphocytes: The UCLA Experience 151
V Interleukin-2 and Other Cytokines
16 T Cell Growth Factors in the Treatment of Renal Cancer 163
17 Overview of Interleukin-2 Trials in Patients with Renal Cell Carcinoma 171
18 Interleukin-2 as a Single Agent in Advanced Renal Cell Cancer 195
19 Interleukin-2 in Patients with Metastatic Renal Cell Carcinoma: Efficacy and Tolerance to a New Schedule 201
20 Pharmacology of Recombinant Human Interleukin-6 205
21 Immunologic Effects and Antimetastatic Activity of Recombinant Human Interleukin-7 in Mice 219
VI Combination Therapy with Cytokines
22 Tumor Necrosis Factor and Interferon-[alpha][subscript 2]: A Successful Approach to Metastatic Renal Cell Carcinoma 231
23 Trials with Tumor Necrosis Factor and Interferon-[gamma] in Renal Carcinoma 247
24 Immunotherapy of Patients with Metastatic Renal Cell Carcinoma Using an Outpatient Regimen of Interleukin-2 and Interferon-[alpha]: UCLA School of Medicine 261
25 Phenotypic and Functional Analysis of Lymphoid Cells in the Peripheral Blood and Tumor of Cancer Patients Treated with Recombinant Interleukin-2 plus Interferon-[alpha]
26 Treatment of Metastatic Renal Cell Carcinoma with High-Dose Interferon and Prednisone 297
27 Interleukin-2 and Interferon-[alpha] in Renal Cell Carcinoma: Europe 305
VII Chemotherapy and Chemoimmunotherapy
28 Interleukin-2 and Vinblastine for Renal Cell Carcinoma 315
29 Kidney Cancer: Chronochemotherapy 325
Index 343