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Preface
Contributors
1 The IL-3, GM-CSF, IL-5 Receptor Family 1
2 Tyrosine Kinases and Phosphatases in Hematopoietic Growth Factor Signaling 19
3 The Raf/Map Kinase Pathway: A Protein Kinase Cascade Mediating Signal Transduction Shared by Multiple Cytokines 49
4 Transcription Factors in the Mitogenic Response to Growth Factors 63
5 Modulation of Cell Function by Colony-Stimulating Factors for Granulocytes and Granulocytes/Macrophages 85
6 Granulocyte-Macrophage Colony-Stimulating Factor 99
7 Interleukin-3: From Molecular Biology to Clinical Use 135
8 Hematopoietic Effects of Recombinant Human Granulocyte Colony-Stimulating Factor 165
9 Interleukin-1: Biological Effects in Human Hematopoiesis 189
10 Economic Aspects of Therapy with Hematopoietic Growth Factors 205
11 Peripheral Blood Progenitor Cells: Mobilization, Enrichment, Ex Vivo Expansion, and Clinical Use 227
12 G-CSF: Role in Bone Marrow and Peripheral Blood Stem Cell Transplantation 241
13 GM-CSF and M-CSF in Autologous and Allogeneic Stem Cell Transplantation 257
14 Interleukin-9 285
15 Biological Activities and Clinical Potential of Interleukin-10 295
16 Interleukin-11: Biological and Clinical Perspective 315
17 Natural Killer Cell Stimulatory Factor/Interleukin-12: Biology and Potential Clinical Use 337
18 Chemokines 357
19 The In Vivo Hematopoietic Role of Stem Cell Factor 381
Index 393