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Preface
1 Developmental Control Genes 1
2 Early Response Genes and Renal Growth 15
3 Epithelial Cell Polarity: Molecular Mechanisms 21
4 Regulation of Coordinately Expressed Collagen Genes 33
5 Laminin 41
6 Metalloproteinases 61
7 Molecular Biology of Renin 71
8 Angiotensin II and the Renin-Angiotensin System 91
9 Mineralocorticoid Receptors and Specificity-Conferring Mechanisms 107
10 Endothelin Generation, Receptors, and Cellular Signaling 113
11 The Nitric Oxide Synthase Gene Family 133
12 Adrenergic and Dopamine Receptors 143
13 Molecular Biology of Atrial Natriuretic Peptide in the Kidney 157
14 Kinins and Kidney Function 169
15 Cyclooxygenases 183
16 Renal Prostanoid Receptors 201
17 Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide 215
18 Recent Progress in the Cloning and Characterization of Calcitonin Receptor cDNAs 239
19 Vitamin D and the Plasma Membrane Calcium Pump 253
20 Molecules Involved in Proximal Tubular Apical Na/P[subscript i] Contransport 269
21 Molecular Biology of Chloride Channels 275
22 Anion Exchangers 289
23 Organic Anion Transporters 309
24 Molecular Biology of Renal Sodium-Conducting Ion Channels 319
25 Renal Potassium Channels 335
26 Structure and Regulation of Na,K-ATPase in the Kidney 349
27 Renal Plasma Membrane Vacuolar H[superscript +] ATPases: Properties and Function in Acid-Base Homeostasis 369
28 Na[superscript +]/H[superscript +] Exchangers: Structure, Function, and Regulation 415
29 Calcium Channels 427
30 Glucose Transporter Expression in the Kidney 439
31 Molecular Regulation of Organic Osmolytes in Renal Cells 451
32 Molecular Biophysics of Kidney Water Channels 459
33 Mitogen-Activated Protein Kinase Signaling Cascades 469
34 Heterotrimeric Guanine Nucleotide Binding Proteins 497
35 ADH Receptors: Molecular Biology and Signal Transduction 517
36 Steroid Response Elements 525
37 Transcription Factors in Kidney Development and Renal Injury 535
38 Erythropoietin and Hypoxia-Sensitive Regulation 551
39 Insulin-like Growth Factors in Mature and Developing Kidney 561
40 Cell Biology of Platelet-Derived Growth Factor 573
41 TGF-[beta] in Renal Pathophysiology 591
42 Molecular Regulation of the Heat-Shock/Stress Response: Nephrologists' Perspective 605
43 Interleukin-6 and Interleukin-8 as Potential Inflammatory Mediators of Injury in Renal Diseases 617
44 Interleukin-1: A Master Cytokine in the Renal Response to Injury 631
45 The Monocyte Chemoattractant Protein 1 653
46 Molecular Biology and Function of the Chemoattractant Cytokines RANTES and CSF-1 673
47 Phospholipases A[subscript 2] 681
48 The Renal Plasminogen Activating System 699
49 Leukocyte Adhesion Molecules 717
50 Molecular Biology of Renal Epithelial Antigens 741
51 Molecular Biology Approach to Human Kidney Biopsies 771
52 Wilms' Tumor 783
53 Alport Syndrome 795
54 Goodpasture Syndrome 809
55 Molecular Genetics of Polycystic Kidney Disease 821
56 Molecular Response to Ischemic and Nephrotoxic Acute Renal Failure 839
57 NF-[kappa]B Regulation of HIV-1 Gene Expression: Potential Role in the Pathogenesis of HIV-Associated Nephropathy 855
58 Molecular Features of Nephritogenic Antibodies, T-Cell Receptors, and MHC Molecules 865
59 Platelet-Derived Growth Factor and Renal Disease 875
60 The Molecular Biology of Congenital Nephrogenic Diabetes Insipidus 887
61 Prospects for Gene Therapy in the Kidney 913
Index 923
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