Analysis of Environmental Endocrine Disruptors, Vol. 747

Author: Lawrence H. Keith
Published: October 1999
Publisher: Oxford University Press
ISBN: 084123650X
Hardcover Book
Number of Pages: 173

Click to compare book prices for Analysis of Environmental Endocrine Disruptors, Vol. 747

This book is comprised of a series of papers presented at an ACS Symposium on Endocrine Disrupting Chemicals (EDCs). In ten chapters contributors present the latest information on in vitro and in vivo bioassays for EDCs and on analytic instrumentation and approaches for chemical analysis of EDCs in environmental samples. The purpose is to summarize the current state of knowledge on the assays for EDCs, including monitoring and analytical methods and information on regulatory issues associated with EDCs. The audience is primarily researchers and students in environmental toxicology and ecotoxicology. Chapter 1 is a good introduction of EDCs and the regulatory justification for the focus on these chemicals. Chapter 2 is an interesting discussion of the strengths and weaknesses of ER binding affinity measurements of EDCs. Not much is provided in Chapter 3, and in some places (e.g., Table 2) the relevance is very questionable. Chapter 4 is a good technical summary of the analysis of EDCs in foods but there is not sufficient information to put this into any context. Chapter 5 does not fit in well at all; it simply is a study on the environmental chemistry and transport of pesticides in one selective environment. Chapter 6 is the best chapter in the book,an excellent summary of in vitro and in vivo approaches to monitoring EDCs in the aquatic environment. In Chapter 7 the contribution of municipal wastewater discharge as a source of EDCs is discussed, and this is a valuable contribution. Chapter 8, with a primary focus on pharmaceuticals (e.g. caffeine which is not an EDC), is only of peripheral interest. Chapter 9 is a thorough presentation of MS analysis of EDCs and is a goodaddition to this volume. In Chapter 10 the levels of EDCs in humans is discussed, and important information on synthetic and natural EDCs is provided. This is an important topic and deserving of publication. The inherent problems with publication of symposium papers are evident. There is an inconsistency in style and presentation and some redundancy in the introduction to each chapter. Moreover, there is a lack of logic to the flow of the information presented. From a recent Society meeting in Boston, 10 papers address the effects and emerging issued involving chemicals that might have adverse effects on the endocrine systems of humans, wildlife, and research animals. They consider the results of current efforts to develop screening methods for the disruptors, attempts to develop confirmatory monitoring and measuring methods to complement the screening, and regulatory and policy issues relating to the chemicals in the environment and food. Distributed in the US by Oxford University Press. Keith, Lawrence H. (Waste Policy Institute); Jones-Lepp, Tammy L. (U.S. Environmental Protection Agency); Needham, Larry L. (Centers for Disease Control and Prevention)

Table of Contents
Preface
1 Endocrine Disruptor Screening and Testing: A Consensus Strategy 1
2 Method Development and Interspecies Comparison of Estrogen Receptor Binding Assays for Estrogen Agonists and Antagonists 11
3 Analytical Challenges of Environmental Endocrine Disruptor Monitoring 23
4 Determination of Suspected Endocrine Disruptors in Foods and Food Packaging 33
5 Environmental Exposures to Agrochemicals in the Sierra Nevada Mountain Range 53
6 Instrumental and Bioanalytical Measures of Endocrine Disruptors in Water 73
7 Potential Endocrine Disrupting Organic Chemicals in Treated Municipal Wastewater and River Water 97
8 Detection of Pharmaceuticals Entering Boston Harbor 125
9 Identifying Endocrine Disruptors by High-Resolution Mass Spectrometry 133
10 Levels of Selected Nonpersistent Endocrine Disruptors in Humans 147
Author Index 159
Subject Index 160

Click to compare book prices for Analysis of Environmental Endocrine Disruptors, Vol. 747 Analysis of Environmental Endocrine Disruptors, Vol. 747

Compare Shop Books - Help - About - Book Links - Book Coupons