Systematic Evaluation of the Mouse Eye

Author: Richard S. Smith
Published: December 2001
Publisher: CRC Press
ISBN: 084930864X
Hardcover Book
Number of Pages: 416

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The high degree of similarity between mouse and human genomes and physiology has made mice the laboratory animals of choice in the search for models of human disease. In recent years significant advances in our ability to examine the mouse eye and to view vascular and neural structures in vivo has led to a marked increase in interest in mouse ocular pathology and development. This book provides the first comprehensive and systematic approach to understanding the development, structure, and abnormal pathology of the mouse eye. It describes the normal anatomy, pre- and postnatal development, regional pathology, and methodology for evaluation of the mouse eye and adnexae.

Table of Contents:

Sect. I Regional Anatomy and Development
Ch. 1 The Anterior Segment and Ocular Adnexae 3
Ch. 2 The Posterior Segment and Orbit 25
Ch. 3 Ocular Development 45
Sect. II Issues in Mutant Mouse Evaluation
Ch. 4 Strain Background Disease Characteristics 67
Ch. 5 Selection of Controls 77
Ch. 6 Genetic Approaches to Identifying QTL and Modifiers of Hereditary Ocular Phenotypes 81
Ch. 7 Mutagenesis and Genetic Screens in the Mouse 93
Sect. III Regional Ocular Pathology
Ch. 8 The Anterior Segment 111
Ch. 9 Choroid, Lens, and Vitreous 161
Ch. 10 Retina 195
Ch. 11 Optic Nerve and Orbit 227
Sect. IV Biomethods
Ch. 12 Photography and Necropsy 251
Ch. 13 General and Special Histopathology 265
A Light Microscopy 266
B Electron Microscopy 272
C Immunohistochemistry 277
D Northern and in Situ Hybridization 285
Ch. 14 Other Techniques 299
A Cell Kinetics, Morphometrics, and Confocal Microscopy 300
B Intraocular Pressure Measurement in Mice: Technical Aspects 313
C Electrophysiological Testing of the Mouse Visual System 320
Ch. 15 Resources 345
Index 353

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