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Table of Contents:

Section 1 Carbon Monoxide and Physiological Functions of the Cardiovascular System
Chapter 1 The Physiological Role of Carbon Monoxide Derived from Heme Oxidation Catalyzed by Heme Oxygenase 3
Chapter 2 Carbon Monoxide-Induced Vasorelaxation and the Underlying Mechanisms 23
Chapter 3 Carbon Monoxide and Vascular Smooth Muscle Cell Growth 45
Chapter 4 Signal Transduction Pathways Involved in CO-Induced Vasodilation: The Role of Cyclic GMP/Soluble Guanylyl Cyclase 67
Chapter 5 Carbon Monoxide, Vascular Contractility, and K[superscript +] Channels 83
Chapter 6 Nitric Oxide and the Heme Oxygenase/Carbon Monoxide System: Cooperation in the Control of Vascular Function 111
Chapter 7 Developmental Biology of Heme Oxygenase and Carbon Monoxide in the Cardiopulmonary System 125
Chapter 8 Carbon Monoxide Signaling in the Heart 135
Section 2 Carbon Monoxide and Pathophysiology of the Cardiovascular System
Chapter 9 The Heme--Heme Oxygenase--Carbon Monoxide System and Hypertension 149
Chapter 10 Carbon Monoxide and Cardiovascular Inflammation 165
Chapter 11 Human HO- 1 Deficiency and Cardiovascular Dysfunction 181
Chapter 12 The Roles of Carbon Monoxide in the Pathogenesis of Diabetes and Its Vascular Complications 213
Chapter 13 Selective Increase in Human Heme Oxygenase-1 Gene Expression Attenuates Development of Hypertension and Increases Body Growth in Spontaneously Hypertensive Rats 233
Section 3 Techniques Used in Carbon Monoxide Research
Chapter 14 Studies on the Development of Carbon Monoxide-Releasing Molecules: Potential Applications for the Treatment of Cardiovascular Dysfunction 249
Chapter 15 Sources, Sinks, and Measurement of Carbon Monoxide 273
Index 309