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Table of Contents:

Pt. I General Considerations of using Laboratory Animals
1 Ethics and Regulations for the Care and Use of Laboratory Animals 3
2 Experimental Design, Evaluation Methods, Data Analysis, Publication, and Research Ethics 15
3 Animal Selections in Orthopaedic Research 39
4 Surgical Facilities, Peri-operative Care, Anesthesia, and Surgical Techniques 59
5 Euthanasia and Necropsy 71
Pt. II Evaluation Methods in Orthopaedic Animal Research
6 Methods of Evaluation in Orthopaedic Animal Research 85
7 Histological Study in Orthopaedic Animal Research 115
8 Mechanical Properties and Testing Methods of Bone 139
9 Mechanical Testing of Cartilage 165
10 Mechanical Testing of Ligaments and Tendons 175
Pt. III Animal Models of Bone Conditions
11 Animal Models of Fracture or Osteotomy 197
12 Animal Models for Testing Bioabsorbable Materials 219
13 Animal Models of Bone Defect Repair 241
14 Animal Models of Osteonecrosis 261
15 Animal Models of Osteopenia or Osteoporosis 279
Pt. IV Animal Models of Articular Cartilage and Joint Conditions
16 Animal Models of Articular Cartilage Defect 309
17 Animal Models of Meniscal Repair 327
18 Animal Models of Osteoarthritis 349
19 Animal Models of Rheumatoid Arthritis 369
Pt. V Animal Models of Joint Replacement and Related Conditions
20 Animal Models for Studying Soft Tissue Biocompatibility of Biomaterials 393
21 Animal Models for Studying Bone Ingrowth and Joint Replacement 407
22 Animal Models for Investigations of Biomaterial Debris 427
23 Animal Models of Orthopaedic Prosthetic Infection 443
Pt. VI Animal Models for the Study of Ligaments and Tendons
24 Animal Models of Ligament Repair 461
25 Animal Models of Tendon Repair 477
26 Animal Models for Ligament and Tendon Fixation 491
Pt. VII Animal Models of Spinal Conditions
27 Animal Models of Spinal Instability and Spinal Fusion 505
28 Animal Models of Spinal Cord Compression 527
29 Animal Models for Reconstruction of Vertebral Column and Intervertebral Disc 539
30 Animal Models of Scoliosis 549
Pt. VIII Microsurgical Technique
31 Use of Microsurgical Technique in Orthopaedic Animal Models 567
App. 1: Abbreviations 583
App. 2 Journals and Publications Related to Orthopaedic Research and Laboratory Animals 585
App. 3 Major Sources of Laboratory Animals 587
Index 589