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Endocrine Disruptors: Effects on Male and Female Reproductive Systems

Author: Rajesh K. Naz
Published: January 1999
ISBN: 0849331641
Hardcover Book
Number of Pages: 358
 
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Endocrine Disruptors: Effects on Male and Female Reproductive Systems


Endocrine Disruptors: Effects on Male and Female Reproductive Systems examines the epidemiology and etiology of environmental toxicants, or "hormone imposters," many of which act as reproductive toxicants that cause fertility problems. This book addresses alarming issues such as declining global fertility; rising incidences of breast and prostate cancer; and the wide variety of toxic effects that the synthetic chemicals, termed endocrine disruptors, exert on the gonads, fertility, and sexual and reproductive function.


Table of Contents:


Sect. I Effect on the Female Reproductive System
1 Nontraditional Sites of Endocrine Disruption by Chemicals on the Hypothalamus-Pituitary-Gonadal Axis: Interactions with Steroid Membrane Receptors, Monoaminergic Pathways, and Signal Transduction Systems 3
2 Diethylstilbestrol (DES) and Environmental Estrogens Influence the Developing Female Reproductive System 39
3 Ovotoxic Environmental Chemicals: Indirect Endocrine Disruptors 57
4 Dietary Phytoestrogens 89
5 Estrogens, Xenoestrogens, and the Development of Neoplasms 125
6 Differential Regulation of Gene Expression by Estrogenic Ligands: A Potential Basis for the Toxicity of Environmental Estrogens 165
7 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Environmental Antiestrogens: Characterization and Mechanism of Action 187
Sect. II Effect on the Male Reproductive System
8 Endocrine Disruptors and Male Infertility 225
9 Environmental Antiandrogens as Endocrine Disruptors 247
10 Endocrine Disruptors and Sexual Dysfunction 279
11 The Role of Natural and Manmade Estrogens in Prostate Development 307
12 Metal Ions and Prostate Cancer 329
Index 339


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Endocrine Disruptors: Effects on Male and Female Reproductive Systems





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