Skin Immune System: Cutaneous Immunology and Clinical Immunodermatology

Author: Jan D. Bos
Published: April 1997
Publisher: CRC Press
ISBN: 0849340160
Hardcover Book
Number of Pages: 719

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Immunodermatology is a field covering the majority of skindiseases, including the most prevalent onesin the general population. The Second Edition of Skin Immune System (SIS) discusses immune-mediated skin diseases and disease groups in which the SIS plays a role. It covers major findings in immunophysiology and immunopathology that have occurred since the introduction of the First Edition in 1990. As the subtitle indicates, the Second Edition adds a new emphasis on cutaneous immunology, and also includes new information on immune-based therapeutic interventions and methods, such as phototherapy and the immunological therapy of skin cancer.

The book contains Part I, with introductory chapters; Part II, with descriptions of the cellular elements; and Part III, which describes the humoral and molecular components of SIS. Part IV follows to integrate the facts described in Parts II and III into concepts of pathophysiology. It contains a number of concepts entitled "response patterns" that describe how the constitutional elements of SIS work together. New in this edition are the descriptions of immunodermatological diseases individually described in Part V. Part VI is also all new and summarizes principles of immunotherapy.

Table of Contents:

Introduction
A History of Immunodermatology 3
Skin Immune System (SIS) 9
Comparative Immunology of the Integument 17
Keratinocyte 43
Langerhans Cells and Related Skin Dendritic Cells 59
Lymphocyte Subpopulations of the Skin 85
Macrophages and Dendritic Cells in the Skin 109
Endothelial Cells of Blood and Lymphatic Vessels 147
Mast Cells 159
Neutrophils, Eosinophils, and Basophils in the Skin Immune System 185
Free Radicals 207
Eicosanoids in Inflammatory and Immunological Skin Disorders 227
Complement and Complement Regulatory Molecules 239
Secretory Immunoglobulins 255
The Epidermal Cytokine Network 271
Neuropeptides in the Skin 311
Programmed Cell Death in Cutaneous Immunopathology 327
Epidermis as a Pro-Inflammatory Organ 339
The Dermal Immune System 347
Adhesion Molecules and Inflammatory Cell Migration Pathways in the Skin 365
Immunology of the Hair Follicle 377
Physiology and Pathology of Skin Photoimmunology 399
The Skin Immune System and Tumor Immunosurveillance 417
Some Congenital Immunodeficiencies and Their Dermatological Manifestations 433
Immunobullous Disorders 445
Scleroderma 461
Lupus Erythematosus 471
Cutaneous Vasculitis 479
Urticarial Vasculitis 489
Atopic Dermatitis 497
Allergic Contact Dermatitis 509
Psoriasis 523
Lichen Planus and Graft-vs.-Host Disease 531
Immunology of Vitiligo 543
Viral Infections 555
Bacterial Infections 571
Fungal Infections 593
Parasitic Infections 605
Tumors of Skin Homing Lymphocytes 617
Immunosuppressive Drugs 629
Pharmacological Manipulation of the Complement System in Dermatology 641
Cytokines, Autologous Cell Immunostimulatory, and Gene Therapy for Cancer Treatment 657
Photo(Chemo)Therapeutic Modulation of the Skin Immune System 671
Index 689

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