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Dermatologic Research Techniques

Author: Howard I. Maibach
Published: October 1995
Publisher: CRC Press
ISBN: 0849383730
Hardcover Book
Number of Pages: 273
 
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Dermatologic Research Techniques


Dermatologic Research Techniques describes and defines models indermatology relating to animal, human, computer, and in vitro systems. It provides a valuable overview as well as in-depth evaluation of the rapidly evolving world of dermatologic research models.


Table of Contents:


Ch. 1 The Guinea Pig as a Model for Topical Dermatopharmacology 1
Ch. 2 The Use of Epidermal and Dermal T-Lymphocytes Clones in Studies on the Pathophysiology of Bullous Drug Eruptions 11
Ch. 3 In Vivo Model of Cutaneous Inflammation Induced by Subsets of T Helper Cells in Mice 23
Ch. 4 The Use of Scalp Grafts onto Nude Mice as a Model for Human Hair Growth: Is there Something New for Hair Growth Drug Screening Programs? 37
Ch. 5 Objective Measurements of Skin Color using Reflectance Spectroscopy 51
Ch. 6 Mouse Models for Scaly Skin Disease 61
Ch. 7 Whole Skin Organ Culture as a Tool to Study Hyaluronan and Proteoglycan Metabolism 91
Ch. 8 In Vitro/In Vivo Assessments of Topical Hydrocortisone Availability: Correlation Between Blanching Assay and Laboratory Cell Experiments 113
Ch. 9 A New Model for Testing Phototoxicity of Skin Microorganisms 123
Ch. 10 Drug and Cosmetics Evaluations with Skin Strippings 133
Ch. 11 Drug Concentration in the Skin 151
Ch. 12 The Plastic Occusion Stress Test (POST) as a Model to Barrier Function 179
Ch. 13 Freund's Adjuvant-Induced Skin Lesions in Rats: A Novel Subchronic Model for Assessing Antiinflammatory Agents 187
Ch. 14 A Model to Study the Drying Potential of Detergent formulations on the Skin 195
Ch. 15 Some Aspects of In Vitro Percutaneous Penetration Studies using Radioisotopes 207
Ch. 16 Phototrichogram Analysis of Hair Follicle Stimulation: A Pilot Clinical Study with a Peptide-Copper Complex 217
Ch. 17 Quantitative Assessment of Peptide-Copper Complex-Induced Hair Follicle Stimulation Using the Fuzzy Rat 227
Ch. 18 Evaluation of Telogen Hair Follicle Stimulation Using an In Vivo Model: Results with Peptide-Copper Complexes 241
Ch. 19 Powdered Human Stratum Corneum (PHSC): Model for Interaction of Chemical and Human Skin 255
Index 265


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Dermatologic Research Techniques





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