This detailed and thorough examination of cytochrome P450 will be a useful source for research scientists, especially those working in the pharmaceutical industry, dealing with the safety evaluation of chemicals and the study of their metabolism, pharmacokinetics, and toxicological properties.

Table of Contents:

Ch. 1 Cytochrome P450: From a Single Protein to a Family of Proteins - With Some Personal Reflections 3
Ch. 2 Role of Metabolism in Chemical Toxicity 29
Ch. 3 The Chemistry of Cytochrome P450 Reactions 55
Ch. 4 The CYP1 Family 77
Ch. 5 The CYP2A Subfamily 99
Ch. 6 The CYP2B Subfamily 135
Ch. 7 The CYP2C Subfamily 161
Ch. 8 The CYP2D Subfamily 183
Ch. 9 The CYP2E Subfamily 211
Ch. 10 The CYP3 Family 241
Ch. 11 The CYP4 Family 271
Ch. 12 Expression of Cytochrome P450 Proteins in Disease 301
Ch. 13 Cytochromes P450 and Immunotoxicity 329
Ch. 14 Molecular Modeling of Mammalian Cytochromes P450 355
Index 399