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List of Contributors
Foreword
Preface
1 Historical Resume 3
2 General Features of the Origin and Pathogenesis of Endocrine Tumors 8
3 Growth Factors in the Pathogenesis of Endocrine Tumors 15
4 Protooncogenes and Tumor-Suppressor Genes in Endocrine Tumors 25
5 Genetic Aspects of Multiple Endocrine Syndromes 36
6 Experimental and Clinical Studies in Hormone-Dependent Cancers 49
7 Pituitary Neoplasms: An Overview of the Clinical Presentation, Diagnosis, Treatment, and Pathology 77
8 Acromegaly 113
9 Prolactinomas 124
10 Thyrotropin-Secreting Tumors 136
11 Gonadotroph Adenomas 152
12 Pituitary Tumors During Pregnancy 167
13 Nonadenomatous Intrasellar and Parasellar Neoplasms 179
14 Radiologic Investigation of Pituitary Tumors 197
15 Surgical Management of Pituitary Tumors 215
16 Classification of Thyroid Tumors 223
17 Iodine Deficiency and Endemic Goiter 228
18 Evaluation and Diagnosis of Nodular Thyroid Disease 233
19 Benign Nodular Thyroid Disease 243
20 Radiation-Associated Thyroid Neoplasms 254
21 Thyroid Carcinoma: Papillary and Follicular 278
22 Medullary Thyroid Carcinoma 334
23 Primary Malignant Thyroid Lymphoma and Related Lymphoproliferative Disorders 348
24 Undifferentiated Thyroid Carcinoma and Unusual Thyroid Malignancies 378
25 The Incidental Adrenal Mass 401
26 Aldosterone-Producing Tumors 408
27 Adrenocortical Carcinoma 422
28 Adrenal Medullary Tumors: Pheochromocytoma 426
29 Neuroblastoma 448
30 Glucagonoma, VIPoma Somatostatinoma, Other Hormones, and Nonfunctional Tumors 457
31 Multiple Endocrine Neoplasia and Gastrinoma 484
32 Insulinoma 497
33 Neural Crest Tumors: Rationale for Somatostatin and Its Analogs in Diagnosis and Therapy 531
34 Ectopic Hormone Syndromes: General Features and Ectopic Vasopressin, Gonadotropin, Hyperthyroidism, Placental Lactogen, Prolactin, and Erythropoietin 543
35 Ectopic Adrenocorticotropic Hormone 554
36 Hypercalcemia Associated with Malignant Tumors 567
37 Parathyroid Hormone-Related Protein and Hypercalcemia in Cancer 592
38 Metabolic Bone Diseases Associated with Malignancy: Osteoporosis and Osteomalacia 608
39 Hyperparathyroidism 625
40 The Calcitonin Gene Peptide Family: Molecular Biology, Physiology, Pharmacology, and Relations to Malignancy 671
41 Hypoglycemia Due to Production of Hypoglycemic Factors by Nonislet-Cell Tumors 687
42 Carcinoid Tumors 700
43 Thymoma 723
44 Endocrine Aspects of Prostate Tumors 733
45 Testicular Tumors: Clinically Relevant Histologic Findings 760
46 Germ-Cell Cancer of the Testis 776
47 Breast Cancer 818
48 Sex-Cord Stromal Tumors of the Ovary 849
49 Endocrine Complications of Cancer Treatment 857
Index 867