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Table of Contents:

Preface v
Foreword vii
Contributors xv
Part I Cutaneous Carcinogenesis 1
1. History of Cutaneous Carcinogenesis 2
2. Multistage Mouse Model of Skin Carcinogenesis and Cell Cycle Regulation 8
3. Molecular Model of Cancer Development 19
4. Development of Metastases 30
5. Immune Surveillance Mechanisms 39
6. Skin Cancer in the Immunosuppressed Host 51
7. Differentiation Pathways 61
8. Cytokines and Growth Factors 73
9. Retinoids 87
10. The Role of Aging 92
11. Tumor-Stroma Interactions 98
12. Tumor Dormancy 105
13. DNA Damage and Repair 110
14. Mechanisms of Ultraviolet Radiation: Carcinogenesis and Immune Suppression 115
15. Epidemiology of Ultraviolet Radiation 121
16. The Ozone Layer 129
17. Ionizing Radiation 134
18. Chemicals 141
19. Viruses 148
20. Genetic Syndromes Predisposing to Skin Cancer Development 158
21. The Public Health Approach to Prevention of Skin Cancer 169
22. Chemoprevention of Skin Cancer 175
Part II Melanoma 179
23. History of Melanoma 180
24. Molecular Biology 183
25. Cell Structure and Function 200
26. Cellular Immunobiology 211
27. Biologic Factors 218
28. Precursor Melanocytic Lesions 224
29. Environmental and Host Risk Factors 235
30. Pregnancy and Estrogen 243
31. Follow-up Evaluation of Patients at Risk 250
32. Clinical Presentation 253
33. Histology 262
34. Factors Predictive of Metastasis and Outcome 278
35. Clinical Presentation and Diagnosis of Metastasis 292
36. Therapy of Melanoma In-situ (Lentigo Maligna) 297
37. Surgical Treatment of Stage I and II Disease (Excision, Lymphadenectomy, Limb Perfusion) 303
38. Radiation Therapy of Stage I and II Disease 316
39. Adjuvant Therapy of Stage I and II Disease 323
40. Therapy of Stage III and IV Disease 331
41. New Horizons and Research Techniques 342
Part III Squamous Cell Carcinoma 349
42. History of Squamous Cell Carcinoma 350
43. Molecular Biology 353
44. Cell Structure and Function 361
45. Cellular Immunobiology 373
46. Effects of Biological Factors 379
47. Risk Factors 382
Color Plates Section 391
48. Predisposing Genetic Syndromes and Clinical Settings 457
49. Clinical Presentation 468
50. Histology 481
51. Features Associated with Recurrence 494
52. Features Associated with Metastasis 500
53. Surgical Management of Local Disease 506
54. Cryosurgery 518
55. Radiation Therapy 526
56. Lasers and Photodynamic Therapy 534
57. Biologic Response Modifiers 542
58. Topical Chemotherapy 547
59. Surgery and Radiation Therapy for Advanced Disease 553
60. Chemotherapy and Biologic Response Modifiers for Advanced Disease 558
61. Follow-up and Prevention 565
62. Research Techniques and New Horizons 571
Part IV Basal Cell Carcinoma 577
63. History of Basal Cell Carcinoma 578
64. Pathogenesis 581
65. Molecular Genetics 586
66. Cell Structure and Function 592
67. Cellular Immunobiology 599
68. Biologic Factors 604
69. Aggressive versus Nonaggressive Subtypes 609
70. Risk Factors 614
71. Predisposing Genetic Syndromes and Clinical Settings 619
72. Clinical Presentation 625
73. Histology 633
74. Features Associated with Recurrence 646
75. Features Associated with Metastasis 657
76. Surgical Management of Local Disease 664
77. Cryosurgery 672
78. Radiation Therapy of Local Disease 676
79. Lasers and Photodynamic Therapy 678
80. Biologic Response Modifiers 681
81. Topical Chemotherapy 687
82. Adjuvant Therapy of Local Disease 691
83. Follow-up and Prevention 695
84. Regional and Distant Metastatic Disease 699
85. Research Techniques and New Horizons 702
Part V Other Cutaneous Tumors 709
86. Merkel Cell Carcinoma 710
87. Microcystic Adnexal Carcinoma 722
88. Primary Cutaneous Adenoid Cystic Carcinoma 729
89. Malignant Eccrine Spiradenoma 734
90. Malignant Clear Cell Hidradenoma 738
91. Malignant Chondroid Syringoma 745
92. Eccrine Porocarcinoma 752
93. Eccrine Mucinous Carcinoma 758
94. Malignant Cylindroma 763
95. Malignant Hidradenoma Papilliferum 769
96. Apocrine Carcinoma 772
97. Paget's Disease of the Nipple 781
98. Extramammary Paget's Disease 789
99. Malignant Ceruminoma 796
100. Sebaceous Gland Carcinoma 800
101. Pilomatrix Carcinoma 811
102. Overview of Soft-Tissue Sarcomas 816
103. Dermatofibrosarcoma Protuberans 822
104. Fibrosarcoma 832
105. Atypical Fibroxanthoma 835
106. Malignant Fibrous Histiocytoma 844
107. Liposarcoma 852
108. Angiosarcoma 861
109. Kaposi's Sarcoma 873
110. Hemangiopericytoma 887
111. Leiomyosarcoma 893
112. Cutaneous Rhabdomyosarcoma 897
113. Malignant Peripheral Nerve Sheath Tumor 902
114. Malignant Granular Cell Tumor 907
115. Epithelioid Sarcoma 915
116. Cutaneous T-Cell Lymphoma 921
117. Cutaneous B-Cell Lymphomas 954
118. Cancers Metastatic to the Skin 964
Index 973