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Preface
Contributors
Sect. I Lung Growth and Development
Ch. 1 The Development of Concepts of the Ontogeny of the Pulmonary Circulation 3
Ch. 2 The de Novo Formation of Blood Vessels in the Early Embryo and in the Developing Lung 19
Ch. 3 Early Development of the Vascular System of the Mouse Lung: Ontogeny of Endothelial Cell Heterogeneity 31
Ch. 4 Structural Elements of Human Fetal and Neonatal Lung Vascular Development 37
Sect. II Vascular Cell Growth and Differentiation
Ch. 5 Contribution of the Adventitial Fibroblast to Pulmonary Vascular Disease 67
Ch. 6 The Role of Thrombospondins 1 and 2 in Vascular Development 87
Ch. 7 Elastic Fiber Proteins in Pulmonary Vascular Development 105
Ch. 8 Proteolytic Modulation of the Extracellular Matrix 117
Ch. 9 Signal Transduction Kinases in the Regulation of Matrix Metalloproteinase-9 Expression in Vascular Smooth Muscle Cells 131
Ch. 10 Transcription Factors Controlling Cellular Proliferation During Vascular Repair 137
Ch. 11 Perlecan Heparan Sulfates in the Control of Vascular Smooth Muscle Cell Proliferation 149
Ch. 12 B-Myb Represses Collagen Gene Expression in Bovine Vascular Smooth Muscle Cells 171
Ch. 13 Mechanical Forces in Vascular Growth and Development 201
Sect. III Mechanisms of Hemodynamic Control in the Neonate
Ch. 14 Lung Arteriolar Endothelial Cell Proliferation at Birth: Possible Roles of Stretch and Hypoxia 215
Ch. 15 Physiologic Roles of Nitric Oxide in the Perinatal Pulmonary Circulation 239
Ch. 16 Regulation of Endothelial Nitric Oxide Synthase Expression in the Developing Lung 261
Ch. 17 The Role of Endothelin in Perinatal Pulmonary Vasoregulation 279
Ch. 18 O[subscript 2]-Sensitive K[superscript +] Channel Activity in the Ovine Pulmonary Circulation Shifts with Maturation 303
Ch. 19 Regulation of Ion Channels in the Ductus Arteriosus 319
Ch. 20 Cytochrome P450 in the Contractile Tone of the Ductus Arteriosus: Regulatory and Effector Mechanisms 331
Ch. 21 Maturational Changes in the Human Pulmonary Vascular Resistance 343
Ch. 22 The Pulmonary Vasculature in Congenital Diaphragmatic Hernia 355
Index 379