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Dedication
Special Dedication to Dr. Harry M. Zimmerman
Introduction
Contributors
Sect. I Basic Science 1
1 Advances in the Study of Glial Lineage 3
2 The Actin-Cytoskeleton and Glial Cell Transformation: Dissecting the Molecular Dynamics of Tumorigenesis 35
3 The Fibrinolytic System in Human Brain Tumors: Association with Pathophysiological Conditions of Malignant Brain Tumors 49
4 Fibroblast Growth Factors in Astrocytomas 69
5 Angiogenesis Inhibition in the Treatment of CNS Tumors 81
6 Protein Kinase C Inhibition, a Potential Therapeutic Strategy for Malignant Glial Tumors: A Summary of Preliminary Results and Future Directions 97
Sect. II Diagnosis 113
7 Imaging Update 115
8 Molecular Neuropathology in Brain Tumor Diagnosis 139
Sect. III Therapy 179
9 Cortical Mapping in Tumor Resection 183
10 Ultrasonic Characteristics of Brain Tumors 191
11 Intraoperative Neurophysiological Monitoring During Removal of Brain Tumors 207
12 Stereotactic Radiosurgery for Benign and Malignant Diseases of the Brain 219
13 Surgery for Spinal Metastases 259
14 Radiobiology Update 283
15 Radiotherapy Management of Brain Tumors 307
16 Chemotherapy of Brain Tumors 331
17 Chemotherapy and Pediatric Brain Tumors 363
18 Chemosensitivity Testing Human Malignant Brain Tumors 413
19 The Treatment of Brain Tumors with Drug-Impregnated Biodegradable Polymers 435
20 Immunobiology of Malignant Gliomas 447
21 Interleukin-2, the Cerebrovasculature, and the Treatment of Malignant Glioma 469
22 Cellular Therapy of Brain Tumors: Clinical Trials 487
23 Targeted Toxin Therapy 505
24 Herpes Simplex Gene Therapy Vectors for the Treatment of Cancer 517
25 Genetic Approaches for the Therapy of Malignant Brain Tumors 541
Index 553