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Contributing Authors
Preface to First Edition
Preface to Second Edition
I Normal Mineral Metabolism 1
1 Renal Handling of Calcium and Phosphorus 3
2 Physiology and Pathophysiology of Renal Magnesium Handling 34
3 Intestinal Absorption of Calcium, Magnesium, and Phosphorus 48
4 Parathyroid Hormone-Synthesis and Secretion 74
5 Target Tissue Actions, Metabolism, and Assay of Parathyroid Hormone 102
6 Parathyroid Hormone-related Protein 129
7 Vitamin D: Synthesis, Metabolism, and Clinical Measurement 157
II Bone Structure and Biology 175
8 Embryology, Anatomy, and Microstructure of Bone 177
9 The Cell and Molecular Biology of Bone Formation 199
10 Mechanisms of Biomineralization 227
11 Mechanisms and Regulation of Bone Resorption by Osteoclastic Cells 235
12 Biology, Chemistry, and Biochemistry of the Mammalian Growth Plate 255
13 Bone Remodeling 315
III Mineral Metabolism During the Human Life Cycle 345
14 Mineral Metabolism during Pregnancy and Lactation 347
15 Bone and Mineral Metabolism during Childhood 360
16 Integration of Calcium Metabolism in the Adult 381
IV Introduction to Clinical Mineral Disorders 397
17 Clinical and Laboratory Approach to the Patient with Disorders of Bone and Mineral Metabolism 399
18 Bone Mass Measurement 406
19 Radiologic Imaging of Metabolic Bone Disease 428
20 Clinical Use of Bone Biopsy 448
21 Physiologic and Pathogenetic Significance of Bone Histomorphometric Data 469
V Disorders of Serum Mineral Levels 487
22 Hypercalcemic States: Differential Diagnosis and Acute Management 489
23 Primary Hyperparathyroidism 516
24 Disorders of Serum Minerals Caused by Cancer 535
25 Hypercalcemia and Abnormal Vitamin D Metabolism 557
26 The Hypocalcemic States 568
27 Disorders of Phosphate and Magnesium Metabolism 589
VI Disorders of Stone Formation 617
28 Physical-Chemical Processes in Kidney Stone Formation 619
29 Mechanisms of Stone Description and Dissolution 629
30 Idiopathic Hypercalciuria 673
31 Hyperoxaluric States 698
32 Calcium Nephrolithiasis and Renal Tubular Acidosis 717
33 Inhibitors and Promoters of Calcium Oxalate Crystallization: Their Relationship to the Pathogenesis and Treatment of Nephrolithiasis 741
34 Noncalcium Urinary Calculi 776
VII Disorders of Bone 803
35 Primary Osteoporosis 805
36 Treatment of Osteoporosis 831
37 Secondary Forms of Osteoporosis 847
38 Bone Disease in Chronic Renal Failure and after Renal Transplantation 865
39 Bone Disease Resulting from Inherited Disorders of Renal Tubule Transport and Vitamin D Metabolism 898
40 Bone Disease Due to Nutritional, Gastrointestinal and Hepatic Disorders 918
41 Hereditary Metabolic and Dysplastic Skeletal Disorders 937
42 Paget's Disease of Bone 985
43 Primary Cystic and Neoplastic Diseases of Bone 1021
Subject Index 1051