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Contributing Authors
Preface
Acknowledgments
Basic Principles
1 Anatomy and Physiology of the Kidney: A Brief Review 1
2 Functional Assessment of the Kidney 37
General Features and Mechanisms of Nephrotoxicity
3 Overview of Clinical Nephrotoxicity 61
4 Morphological Features of Acute Renal Failure 99
5 Pathophysiology of Acute Renal Failure 129
6 Mechanisms of Glomerular Injury 153
7 Biochemical Heterogeneity and Site-Specific Tubular Injury 201
Specific Nephrotoxicants: Therapeutics
8 Nephrotoxicity of Protein Overloading 249
9 The Nephrotoxicity of [beta]-Lactam Antibiotics 257
10 The Nephrotoxicity of Antineoplastic Drugs 283
11 Analgesic Nephrotoxicity 303
12 Nephrotoxicity of Cyclosporine and Other Immunosuppressive and Immunotherapeutic Agents 319
13 Pathogenesis and Therapeutic Aspects of Radiocontrast-Induced Renal Dysfunction 361
Specific Nephrotoxicants: Environmental Chemicals
14 Aliphatic Halogenated Hydrocarbons 387
15 Nephrotoxicity of Bromobenzene: The Role of Quinone-Thioethers 415
16 Mechanisms of Metal-Induced Nephrotoxicity 437
17 Effects of Selected Fungal Toxins on Renal Function 459
18 Male Rat-Specific Light Hydrocarbon Nephropathy 477
19 Renal Carcinogenesis 495
Subject Index 539