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Table of Contents:

Preface
Contributors
1 Endothelium-Derived Relaxing Factor: An Overview 3
2 Ionic Mechanisms of Peptide-Induced Responses in Vascular Endothelial Cells 21
3 Non-cGMP, Paracrine Effects of Nitric Oxide in the Vasculature 37
4 The Endothelin Peptides: Roles in Physiology and Pathophysiology 49
5 Estrogen and Vascular Reactivity 67
6 C-Type Natriuretic Peptide: The Vascular Component of the Natriuretic Peptide System 79
7 Vascular Actions of Insulin in Health and Disease: Role of the Endothelium 95
8 Angiotensin-Nitric Oxide: Interaction and the Regulation of Renal Vascular Tone 109
9 Altered Endothelial Function in Diabetes Mellitus: An Overview 125
10 Vascular Abnormalities in Diabetes Mellitus 135
11 Effects of Hyperglycemia on Vascular Endothelium Nitric Oxide Metabolism 145
12 Evidence Linking Fatty Acids, the Risk Factor Cluster, and Vascular Pathophysiology: Implications for the Diabetic Hypertensive Patient 157
13 Effects of Low Density Lipoproteins on Endothelial Cell Signaling and Adhesion Molecule Expression 173
14 Angiotensin II Signal Transduction in Vascular Smooth Muscle 187
15 The Vascular Renin System 205
16 Effects of Insulin on Vascular Smooth Muscle Contraction 215
17 Sex Hormones and the Vasculature 225
18 Vitamin D and the Vessel Wall 239
19 Vascular Action Natriuretic Peptide Receptors 255
20 A Novel Vascular Hormone: Adrenomedullin 269
21 Calcium and Magnesium in the Regulation of Smooth Muscle Function and Blood Pressure: The Ionic Hypothesis of Cardiovascular and Metabolic Diseases and Vascular Aging 283
22 Regulation of Intracellular pH and the Na[superscript +]/H[superscript +] Antiporter in Vascular Smooth Muscle 301
23 Endocrine Regulation of Vascular Smooth Muscle Intermediary Metabolism 325
24 Analogy Between Endothelial/Mesangial Cell and Endothelial/Vascular Smooth Muscle Cell Interactions: Role of Growth Factors and Mechanotransduction 341
25 Arachidonic Acid Metabolites in the Vasculature 357
26 Arachidonic Acid Metabolites on Renin and Vascular Smooth Muscle Cell Growth 373
Index 389