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Only those diseases likely to be amenable to transplant therapy within the next five years are considered, including Parkinson's disease, Huntington's disease, demyelinating diseases, stroke and pain. All chapters are relevant to both basic scientists and clinicians who are either in the field or are considering starting a clinical program for neural reconstruction.

Table of Contents:

Foreword
Preface
Contributors
1 The Lund Transplant Program for Parkinson's Disease and Patients with MPTP-Induced Parkinsonism 1
2 Fetal Nigral Transplantation in Parkinson's Disease: The USF Pilot Program (12- to 24-Month Evaluation) 19
3 Toward a Phase III Multicenter Study of Fetal Ventral Mesencephalic Transplants in Patients with Late-Stage Parkinson's Disease 31
4 PET Studies of Transplantation Therapy 45
5 Neuropathology of Dopaminergic Transplants in Patients with Parkinson's Disease 51
6 Fetal-Tissue Transplantation for Huntington's Disease: Preclinical Studies 77
7 Fetal Transplantation for Huntington's Disease: Clinical Studies 95
8 Topographic Factors Affecting the Functional Viability of Dopamine-Rich Grafts in the Neostriatum 135
9 Immunological Issues in Rodent and Primate Transplants (Allografts) 171
10 Transplanting Fetal Neural Xenogeneic Cells in Parkinson's and Huntington's Disease Models 189
11 Animal Models of Cerebral Ischemia: Neurodegeneration and Cell Transplantation 211
12 Transplantation Strategies for the Treatment of Pain 231
13 Treatment of Central Nervous System Diseases with Polymer-Encapsulated Xenogeneic Cells 253
14 Transplant Strategies in Myelin Disorders 287
15 Somatic Gene Transfer and Cell Transplantation Strategies for Neurodegenerative Diseases 303
16 Adequately Respecting and Protecting Fetal Tissue Donors and Their Next-of-Kin 333
Index 339