Gene Therapy for Neurological Disorders and Brain Tumors

Author: E. Antonio Chiocca
Published: October 1997
Publisher: Humana Press
ISBN: 0896035077
Hardcover Book
Number of Pages: 458

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Drs. Chiocca and Breakefield bring together in Gene Therapy for Neurological Disorders and Brain Tumors many of the leading gene therapy researchers and clinicians to capture the breadth of the field - from basic vector technology to current and future clinical applications. The authoritative contributions provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorders, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Gene Therapy for Neurological Disorders and Brain Tumors illuminates the rapidly developing applications of gene transfer technologies to the treatment of a wide range of neurological disorders and brain tumors. Readers will learn the current delivery methods for transgenes, will learn the characteristics of the transgene delivery vectors, and come to more fully understand gene therapies for both neuro-oncologic and neurologic disorders.

Table of Contents:

Preface
List of Contributors
Pt. I Vectors and Promoters
Vectors for Gene Delivery to the Central Nervous System: An Overview 3
1 Retrovirus Vectors and Regulatable Promoters 7
2 Characteristics of Adenovirus Vectors 39
3 HSV Recombinant Vectors: General Characteristics and Potential for Use in the Central Nervous System 53
4 HSV-1 Amplicon 63
5 AAV Vectors: General Characteristics and Potential for Use in the Central Nervous System 83
6 EBV Vectors: General Characteristics and Potential for Gene Therapy in the Central Nervous System 93
7 Lentiviral Vectors for Gene Delivery in the Central Nervous System 113
8 Promoters for Expressions of Gene Products Within Neurons and Glia 121
9 Immune Response to Viral Vectors 147
Pt. II Neuro-oncology
10 Current Treatment Modalities for Brain Tumor: Surgery, Radiation, and Chemotherapy 161
11 Experimental and Clinical Gene Therapies for Brain Tumors 191
12 Tumor Suppressor Gene Therapy for Brain Tumors 205
13 Cytokine-Based Gene Therapy for Brain Tumors 231
14 Delivery of Therapeutic Genes to Brain and Intracerebral Tumors 295
15 Rat Brain Tumor Models and Statistical Evaluation of Survival Data in Experimental Neuro-Oncology 313
Pt. III Neurological Disorders
Neurological Disorders: An Overview 341
16 Gene Transfer for Adult CNS Regeneration and Aging 345
17 Gene Therapy for Parkinson's Disease 377
18 Gene Therapy for Ischemic Stroke 397
19 Gene Therapy for the Lysomal Storage Diseases 409
20 Gene Therapy for Pain 419
21 Gene Therapy of Huntington's Disease 427
Index 445

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