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Table of Contents:

Preface
Contributors
Pt. I Hormonal Control of Mammary Development and Growth
1 Hormonal Control of Normal Breast Morphology and Function 3
2 Interactions Between Estradiol and Progesterone in Normal Breast: Implications for Mammary Carcinogenesis 21
3 Expression and Regulation of Insulin-like Growth Factors and Their Binding Proteins in the Normal Breast 39
Pt. II Carcinogenesis
4 Estrogens and Breast Cancer: An Epidemiologic Perspective 55
5 Androgens, Estrogens, and Breast Cancer Risk 69
6 Local Estrogen Production: Is Aromatase An Oncogene? 79
7 Oncogenes and Mammary Carcinogenesis 93
8 Categorization of Breast Cyst Fluid and Breast Cancer Risk 109
Pt. III Tumor Progression
9 The Role of Tumor Suppressor Genes in Breast Cancer Progression 119
10 Oncogene Activation and Breast Cancer Progression 133
11 Interactions Between Stroma and Epithelium in Breast Cancer: Implications for Tumor Genesis, Growth, and Progression 155
12 The Role of Angiogenesis in the Transition to Hormone Independence and Acquisition of the Metastatic Phenotype 169
13 Role of the IGF System in Breast Cancer Proliferation and Progression 187
14 Prognostic and Predictive Factors in Breast Cancer 205
15 Role of the Polyamine Pathway in the Natural History of Breast Cancer 221
Pt. IV Estrogen, Progestins, and Prolactin in Breast Cancer Biology: Targets for Treatment
16 Aromatase Inhibitors in Breast Carcinoma 233
17 Role of Progestins and Progesterone Receptors in Breast Cancer Biology 245
18 Prolactin and its Receptors in Human Breast Cancer 261
Pt. V Endocrine Therapy of Breast Cancer
19 Pharmacology and Use of Antiestrogens in Treatment and Chemoprevention of Breast Cancer 283
20 LHRH Superagonists and Antagonists in the Treatment of Breast Cancer 313
Pt. VI Benign Breast Disease
21 Benign Breast Lesions: Pathologic Classification and Risk Potential 331
22 Hormonal Treatment of Fibrocystic Disease 347
23 Gynecomastia and Galactorrhea 359
Index 383